摘要
目的探讨不同水平氯化钠溶液超声雾化吸入治疗小儿毛细支气管炎的效果。方法选取2017年6月至2018年10月于该院儿科住院的1 450例毛细支气管炎患儿作为研究对象,应用随机数字表法分为A、B、C、D 4组,每组均采用复方丙托溴铵气雾剂1.25mL、布地奈德混悬液1mL雾化吸入,之后A组超声雾化吸入2mL注射用水,B、C、D组分别超声雾化吸入2mL 0.9%、3.0%、5.0%氯化钠溶液,对4组患儿治疗前后进行临床严重度评分,观察治疗后患儿临床症状改善(喘息缓解、咳嗽缓解、肺部哮鸣音消失、肺部湿啰音消失)情况、住院时间、炎症因子[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、干扰素-γ(INF-γ)、肿瘤坏死因子-α(TNF-α)]表达情况和治疗过程中不良反应发生情况。结果与治疗前比较,4组患儿治疗3d后临床严重度评分均降低(P<0.05)。与A组比较,B组机体炎性反应减轻(P<0.05),临床症状改善情况和住院时间差异均无统计学意义(P>0.05);C、D两组的喘息缓解时间、咳嗽缓解时间、肺部哮鸣音消失时间、肺部湿啰音消失时间和住院时间均短于A、B两组(P<0.05);与C组比较,D组临床症状改善更明显,住院时间减少(P <0.05)。A、B、C、D组不良反应发生率分别为0、0、1.39%、1.64%,组间比较差异均无统计学意义(P>0.05)。与治疗前比较,4组患儿治疗后的IL-6、hs-CRP及TNF-α水平均明显降低,IFN-γ水平明显升高(P <0.05)。结论与超声雾化吸入注射用水和0.9%氯化钠溶液比较,3.0%和5.0%氯化钠溶液更有利于降低患儿临床病情严重程度及缩短患儿临床症状缓解时间、住院时间,减轻机体炎性反应,在一定范围内增加氯化钠水平,疗效更明显,且不会增加不良事件的发生率。
Objective To compare the effects of different concentrations of sodium chloride solution in the treatment of children with bronchiolitis by ultrasonic atomization inhalation.Methods A total of 1 450 children with bronchiolitis hospitalized in the department of pediatrics from June 2017 to October 2018 were collected as subjects.There patients were divided into A,B,C,D four groups by random number table method.Each group adopted compound C bromide aerosol 1.25 mL,budesonide suspension liquid 1 mL atomization inhalation.After that,group A was atomized with water for injection,while group B,C and D were atomized with 2 mL of 0.9%,3.0%and 5.0% sodium chloride solutions,respectively.Clinical severity score were performed before and after the treatment for four groups of children.The clinical symptoms improvement(wheezing,cough easing,lung wheezing sound,lung wet then disappear)after treatment,length of hospital stay,inflammatory factor[Interleukin-6(IL-6),high sensitivity C-reactive protein(hs-CRP),interferon-γ(INF-γ),tumor necrosis factor-α (TNF-α)]expression and adverse reactions occurred during treatment were observed.Results Compared with before treatment,the clinical severity scores of the four groups of children were all decreased after 3 days of treatment(P<0.05).The body′s inflammatory response compared with group A,group B reduced(P<0.05),the clinical symptoms improved and no statistically significant difference were observed in the length of hospital stay(P>0.05);Compared with A,B groups,C,D groups of wheezing,cough easing,lung wheezing sound,lung wet then disappear and length of hospital stay were shorter(P<0.05);Compared with group C,group D showed significant improvement in clinical symptoms and hospital stay were reduced(P<0.05).The incidence of adverse reactions in groups A,B,C and D was 0,0,1.39%and 1.64%,respectively,with no statistically significant difference between the groups(P>0.05).Conclusion Compared with ultrasonic atomization inhalation water for injection and 0.9%sodium chloride soluti
作者
田文娟
李晓玲
扈媛媛
TIAN Wenjuan;LI Xiaoling;HU Yuanyuan(Department of Pediatrics,People's Hospital of Ankang,Ankang,Shaanxi 725000,China)
出处
《检验医学与临床》
CAS
2020年第3期315-318,共4页
Laboratory Medicine and Clinic
基金
陕西省自然科学基金项目(20184123)
关键词
毛细支气管炎
氯化钠溶液
超声雾化吸入
高渗盐水
bronchiolitis
sodium chloride solution
ultrasonic nebulization
hypertonic saline
