期刊文献+

1例卵巢颗粒细胞瘤的诊疗报道 被引量:3

Diagnosis and treatment of ovarian granulosa cell tumor:a case report
下载PDF
导出
摘要 卵巢颗粒细胞瘤(GCTs)是一种低度恶性性索间质肿瘤,因其发病较罕见,尚无统一规范的治疗方案。GCTs有内分泌功能,故早期可有女性化特征性表现,主要临床症状为阴道异常流血流液及腹部包块。早期应尽早手术治疗,Ⅱ期以上或有高危因素患者可补充术后辅助治疗。其有远期复发的特点,应注意终生随访。本文通过回顾性分析1例卵巢颗粒细胞瘤患者(IC2期,伴腹腔转移)的治疗案例,并复习相关文献,总结诊疗要点,分享相关临床经验。 Granulosa cell tumors of ovary(GCTs)is a sex cord-stromal tumor which is a lower malignant.The incidence is relatively rare and there is no standardized management.Because of its endocrine function,it can express feminized characteristics in the early stage.The main clinical manifestations are abnormal vaginal bleeding or discharge and abdominal mass.Patients in early stage should choose surgery as soon as possible,and in stageⅡor above or with high risk factors can receive adjuvant therapy after surgery.GCTs has a high rate of long-term recurrence and should be followed up a life long term.This article retrospectively analyzed a patient with GCTs(IC2,with abdominal metastasis),and review related literature,summarized the points of diagnosis and treatment,and shared clinical experience of this disease.
作者 谢文英 王有坤 XIE Wen-ying;WANG You-kun(Department of Oncology,the Third Hospital of Mianyang(the Mental Health Center of Sichuan),Sichuan Province,Miangyang621000,China;Department of Oncology,Mianyang Anzhou District People′s Hospital,Sichuan Province,Mianyang622600,China)
出处 《中国当代医药》 2019年第36期217-219,共3页 China Modern Medicine
关键词 卵巢颗粒细胞瘤 Call-Exner小体 腹腔转移 手术 化疗 放疗 远期复发 Granulosa cell tumors of ovary Call-Exner body Abdominal metastasis Surgery Chemotherapy Radiotherapy Long-term recurrence
  • 相关文献

参考文献2

二级参考文献13

  • 1van Meurs HS, Bleeker MC, van der Velden J, et al. The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study [ J]. Int J Gynecol Cancer, 2013, 23( 8), 1417-1422. DOI: 10.1097/IGC.0b013e3182a57fb4. 被引量:1
  • 2Jamieson S, Fuller PJ. Molecular pathogenesis of granulosa cell tumors of the ovary [ J]. Endocr Rev, 2012, 33 ( 1 ) : 109-144. DOI: 10.1210/er.2011-0014. 被引量:1
  • 3Hines JF, Khalifa MA, Moore JL, et al. Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis : a case report and review of the literature [ J ]. GynecolOncol, 1996, 60 ( 3 ) : 484- 488. DOI: 10.1006/gyno.1996.0078. 被引量:1
  • 4Stine JE, Pierce S, Soper JT. A comprehensive review of diagnostic and treatment options for granulosa cell tumors of the ovary [ J 1. Obstet Gyneco! Surv, 2014, 69( 1 ) : 29-38. DOI: 10.1097/OGX.0000000000000010. 被引量:1
  • 5Kottarathil VD, Antony MA, Nair IR, et al. Recent advances in granulosa cell tumor ovary: a review [ J ]. Indian J Surg Oncol, 2013, 4( 1 ) :37-47. DOI: 10.1007/s13193-012-0201-z. 被引量:1
  • 6van Meurs HS, van Lonkhuijzen LR, Limpens J, et al. Hormone therapy in ovarian granulosa cell tumors: a systematic review [ J ]. Gynecol Oncol, 2014, 134( 1 ) : 196-205. DOI: 10.1016/j.ygyno. 2014.03.573. 被引量:1
  • 7Farinola MA, Gown AM, Judson K, et al. Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors [ J ]. Int J Gynecol Pathol, 2007, 26(4):375-382. DOI:10.1097/pgp.0b013e31805cOd99. 被引量:1
  • 8Heublein S, Mayr D, Friese K, et al. The G-protein-coupled estrogen receptor (GPER/GPR30) in ovarian grattulosa cell tumors [ J ]. Int J Mol Sei, 2014, 15(9):15161-15172. DOI: 10.3390/ijras150915161. 被引量:1
  • 9Fleming NI, Knower KC, Lazarus KA, et al. Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter[ J]. PLoS One, 2010, 5 (12) : e14389. DOI : 10. 1371/journal. pone. 0014389. 被引量:1
  • 10Winemsen W, Kruitwagen R, Bastiaatrs B, et al. Ovarian stimulation and granulosa-cell tumour [ J]. Lancet, 1993, 341 ( 8851 ) : 986- 988. 被引量:1

共引文献7

同被引文献39

引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部