摘要
目的分析高危型人乳头瘤病毒(HR-HPV)阳性液基薄层细胞学检测(TCT)阴性女性的宫颈上皮组织病理学结果。方法收集2015年5月至2018年6月就诊于首都医科大学附属北京妇产医院妇瘤科门诊的1139例女性患者,其宫颈细胞学检查结果未见上皮内病变细胞或恶性细胞,HPV检查结果阳性。所有患者均取宫颈上皮组织进行病理检查及行阴道镜检查,并比较不同型别、不同年龄段HR-HPV感染患者及HPV单纯感染与多重感染患者的宫颈上皮组织病理检查结果。结果不同分型HR-HPV感染患者的宫颈上皮内瘤变(CIN)Ⅱ级及以上病变检出率比较差异有统计学意义(P<0.01),其中宫颈炎症588例(51.62%),CINⅠ级387例(33.98%),CINⅡ~Ⅲ级153例(13.43%),宫颈癌11例(0.97%)。不同年龄段患者的CINⅡ级及以上病变检出率比较差异无统计学意义(P>0.05)。HPV16、HPV18、HPV52单纯感染与多重感染的CINⅡ级及以上检出率比较比较差异无统计学意义(P>0.05);HPV58单纯感染与多重感染的CINⅡ级及以上检出率比较差异有统计学意义(P<0.01)。结论感染HPV16、HPV52、HPV58及25~39岁的女性宫颈上皮组织CINⅡ级及以上病变检出率较高。
Objective To analyze the histopathological results of cervical epithelium in high-risk human papilloma virus(HR-HPV)positive thinprep cytologic test(TCT)negative women.Methods From May 2015 to Jun.2018,1139 female patients were collected from May 2015 to Jun.2018 in the outpatient department of gynecologic incology in Beijing Obstetrics and Gynecology Hospital,Capital Medical University.No intraepithelial pathological cells or malignant cells were found in the cervical cytology,and HPV test was positive in all the cases.The cervical epithelial tissues of all the patients were taken for pathological examination and colposcopy examination,and the pathological examination results of cervical epithelial tissues of patients with different types and ages of HR-HPV infection,and patients with simple and multiple HPV infection were compared.Results The detection rates of cervical intraepithelial neoplasia(CIN)Ⅱand above in patients with different types of HR-HPV infection were statistically significantly different(P<0.01).Among them,588 cases were cervicitis(51.62%),387 cases were CINⅠ(33.98%),153 cases were CINⅡ-Ⅲ(13.43%),11 cases were cervical cancer(0.97%).There was no significant difference in the detection rate of CINⅡand above in patients of different ages(P>0.05).There was no significant difference in the detection rate of CINⅡand above between simple and multiple infection of HPV16,HPV18 and HPV52(P>0.05);there was a significant difference in the detection rate of CINⅡand above between simple infection and multiple infection of HPV58(P<0.01).Conclusion The detection rate of CINⅡand above in cervical epithelial tissue of women infected with HPV16,HPV52,HPV58 and 25-39 years old is relatively high.
作者
周晓花
宋芳
吕讷男
杨淑丽
王彤
王雁
王建东
ZHOU Xiaohua;SONG Fang;LYU Nenan;YANG Shuli;WANG Tong;WANG Yan;WANG Jiandong(Department of Gynecologic Oncology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China)
出处
《医学综述》
2020年第1期183-186,191,共5页
Medical Recapitulate
