摘要
目的观察4种治疗方案对根除儿童幽门螺杆菌感染(Helicobacter Pylori,H.pylori)的疗效。方法200例H.pylori感染患儿随机分到4组,疗程均为14 d。A组(52例):奥美拉唑、阿莫西林联合克拉霉素混悬液;B组(51例):奥美拉唑、阿莫西林联合甲硝唑;C组(45例):奥美拉唑、甲硝唑联合克拉霉素混悬液;D组(52例):奥美拉唑、阿莫西林、克拉霉素混悬液联合枸橼酸铋剂。结果四组治疗方案对H.pylori感染根除率的差异有统计学意义(P<0.05)。A组和D组的根除率均大于90%。结论这些方案均有较高的根除率(≥80%),青霉素过敏患儿推荐C方案,奥美拉唑、阿莫西林联合克拉霉素混悬液组为最佳儿童H.pylori感染根除疗法。
Objective To observe the clinical effects of four treatment regimens in the eradication of Helicobacter pylori(H.pylori)infection in children.Methods A total of 200 children with H.pylori infection were randomly assigned to four groups.The treatment course was 10 d.Group A(n=52)received omeprazole,amoxicillin and clarithromycin;group B(n=51)received omeprazole,amoxicillin and metronidazole;group C(n=45)received omeprazole,metronidazole and clarithromycin;group D(n=52)was given bismuth-based quadruple therapy,including omeprazole,bismuth citrate,amoxicillin and clarithromycin.Results There were significant difference in the eradication rates among the 4 groups(P<0.05).The eradication rates of standard triple therapy(omeprazole,amoxicillin and clarithromycin)and the bismuth-based quadruple therapy were higher than 90%.Conclusion These four treatment regiments have high eradication rates(more than 80%).Patients allergic to penicillin recommend a treatment regimen including omeprazole,metronidazole and clarithromycin.Thestandard triple therapy(omeprazole,amoxicillin and clarithromycin)seems to be the best regimen for the eradication of H.pylori infection in children.
作者
苏莹
陈競芳
卓志强
洪少贤
李明珍
苏艺灵
SU Ying;CHEN Jing-fang;ZHUO Zhi-qiang;HONG Shao-xian;LI Ming-zhen;SU Yi-ling(Department of Gastroenterology,Xiamen Children'Hospital,Children's Hospital of Fudan University Xiamen Branch,Xiamen 361100,China)
出处
《实用药物与临床》
CAS
2020年第1期59-61,共3页
Practical Pharmacy and Clinical Remedies
基金
厦门市科技惠民项目课题(3502Z20174017)
厦门市儿童医院骨干人才培养科研项目(CHP-2019-BT-B001)
