摘要
目的探讨检测体内不同时期尿香草扁桃酸(VMA)、神经元特异性烯醇化酶(NSE)及乳酸脱氢酶(LDH)的水平变化,对小儿神经母细胞瘤(NB)治疗过程中的指导作用。方法对24例已确诊为小儿NB的患儿的临床资料进行回顾性分析,分析患儿在最初确诊时3种特异性肿瘤标记物的阳性率,对比初诊与化疗2个疗程后各指标的检测数值,从而明确对NB的治疗有无指导作用。结果在最初确诊时3种肿瘤标记物阳性率均分别均在85%以上,其中24 h尿VMA阳性率最高,达到93%,其次为NSE,其阳性率88%。经2个疗程化学治疗后,此时,尿VMA、血NSE、LDH的水平均较当初确诊时有明显下降(P<0.05)。结论对特异性肿瘤标记物(VMA、NSE、LDH)的联合检测对NB的治疗具有一定的指导作用。
Objective To investigate the role of urinary vanilla mandelic acid(VMA),neuron specific enolase(NSE)and lactate dehydrogenase(LDH)levels in the treatment of neuroblastoma in children.Methods The clinical data of 24 children with neuroblastoma were analyzed retrospectively.The positive rates of three kinds of tumor markers were analyzed.The detection values of each marker after two courses of treatment were compared between the first diagnosis and the preoperative chemotherapy.The changes of the detection values were observed to determine whether the three markers had a guiding role in the treatment of neuroblastoma.Results The positive rates of the three tumor markers were all over 85%at the first diagnosis.The highest positive rate of VMA in 24 hours urine was 93%,followed by NSE,with a positive rate of 88%.After two courses of chemotherapy,the levels of VMA,NSE and LDH in urine decreased significantly at the first diagnosis(P<0.05).Conclusion The combined detection tumor markers VMA,NSE and LDH may play a guiding role in the treatment of neuroblastoma in children.
作者
吕俊
席红卫
石正峰
崔强强
Lyv Jun;Xi Hongwei;Shi Zhengfeng;Cui Qiangqiang(Department of General Surgery,Shanxi Children′s Hospital,Taiyuan 030002,China)
出处
《实用医技杂志》
2019年第12期1519-1521,共3页
Journal of Practical Medical Techniques
