摘要
目的探讨治疗前18F－脱氧葡萄糖（FDG） PET/CT显像对小儿神经母细胞瘤（NB）预后的预测价值。方法回顾性分析2012年6月至2015年11月间经病理证实且临床及随访资料完备的NB患者27例[男18例、女9例；平均年龄（4.6±2.4）岁]，在患者治疗前行PET/CT显像，分别记录原发肿瘤最大径、原发肿瘤最大标准摄取值（Tmax）、肝脏最大标准摄取值（Lmax）及Tmax/Lmax，同时记录患者临床分期、血清铁蛋白、血清乳酸脱氢酶（LDH）及血清神经元特异性烯醇化酶（NSE）等数据。对患者进行治疗后随访（3～32个月，中位时间24个月），应用Kaplan－Meier法分析Tmax及Tmax/Lmax对患者2年无进展生存（PFS）的影响，应用Cox回归分析探讨各种因素对PFS的影响。结果27例患者中，12例（44.4%）患者病情进展。单变量分析显示，是否存在N－myc基因扩增、血清LDH水平、血清NSE水平、血清铁蛋白水平、原发肿瘤的最大径、Tmax及Tmax/Lmax均对预测2年PFS有价值；多变量分析显示，仅Tmax及Tmax/Lmax是预测2年PFS的独立预后预测因素。结论18F－FDG PET/CT显像能在小儿NB患者预后预测中提供有价值信息。
ObjectiveTo explore the prognostic value of pretreatment 18F-fluorodeoxyglucose （FDG） PET/CT in pediatric neuroblastoma （NB）.MethodsTwenty-seven NB patients （18 males, 9 females; average age （4.6±2.4） years） confirmed by pathology from June 2012 to November 2015 were retrospectively included. All patients had detailed clinical and follow up data. They underwent 18F-FDG PET/CT scan before any treatment, and the largest diameter of primary tumors, maximum standardized uptake value （SUVmax） of primary tumor （Tmax）, SUVmax of liver （Lmax）, Tmax/Lmax ratio, clinical staging, serum ferritin, serum lactate dehydrogenase （LDH） and serum neuron-specific enolase （NSE） were recorded as prognostic factors. Patients were followed up after treatment for 3-32 months （median： 24 months）. Kaplan-Meier survival analysis was used to analyze the influence of Tmax and Tmax/Lmax ratio on 2-year progression free survival （PFS）. Cox regression analysis was used to comprehensive analyze the influence of various factors on PFS.ResultsOf the 27 patients, 12（44.4%） experienced disease progression during the follow-up period. Univariate analysis showed that N-myc gene amplification, serum LDH, serum NSE, serum ferritin, the largest diameter of primary tumors, Tmax and Tmax/Lmax ratio were significant prognostic factors for 2-year PFS. The multivariate analysis showed that only the Tmax and Tmax/Lmax ratio were independent prognostic factors for 2-year PFS.Conclusion18F-FDG PET/CT can provide effective information on the prognostic information for pediatric NB patients.
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2018年第1期33-36,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
