摘要
研究表明,蛋白聚糖和低密度脂蛋白相互作用而使低密度脂蛋白在血管壁滞留、沉积是动脉粥样硬化整个过程中的初发事件。蛋白聚糖通常由一个核心蛋白骨架和一个或多个共价连接的糖胺聚糖链组成,主要有基底膜蛋白聚糖(perlecan)、双糖链蛋白聚糖(biglycan)、多功能蛋白聚糖(versican)、核心蛋白聚糖(decorin)等。在对四类蛋白聚糖进行简要叙述的基础上,现着重对四类蛋白聚糖与低密度脂蛋白的相互作用关系加以综述。
Interactions between proteoglycans and low-density lipoproteins may lead to low-density lipoprotein retention and deposition in the vessel wall,which is an initial event in the entire process of atherosclerosis.Proteoglycans are usually composed of one core protein backbone with one or more glycosaminoglycan chains covalently linked,mainly including perlecan,biglycan,versican,decorin and so on.Thus,with a brief description of these four types of proteoglycans,this review presents the interactions between the four types of proteoglycans and low-density lipoproteins.
作者
陆金燕
杨佳丽
邓小燕
康红艳
LU Jin-Yan;YANG Jia-Li;DENG Xiao-Yan;KANG Hong-Yan(Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China;Beijing Advanced Innovation Center for Biomedical Engineering,Beijing 100083,China)
出处
《生命科学》
CSCD
北大核心
2019年第11期1164-1172,共9页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31870940,11772036,11572028)
