摘要
目的探讨斯钙素⁃2(stanniocalcin2,STC2)在子宫内膜癌中的表达以及与临床诊断中病理因素的相关性。方法对50例子宫内膜癌病人利用半定量RT⁃PCR检测和蛋白质印迹法法检测STC2mRNA和STC2蛋白在子宫内膜癌中表达的情况,分析STC2表达与子宫内膜癌病人在临床诊断中病理因素的相关性。结果在50例子宫内膜癌肿瘤组织中,STC2mRNA相对表达值为2.45±0.27,显著高于癌旁组织1.19±0.13(t=28.5,P=0.0034),STC2蛋白相对表达为1.33±0.27,显著高于癌旁组织0.28±0.05(t=26.4,P=0.0266);STC2的表达与病人的年龄与病理类型无明显关联(χ2=0.028,P=0.743),而与FIGO分期(χ2=10.118,P=0.036)、腺癌病理分化程度(χ2=11.184,P=0.033)及淋巴结转移(χ2=14.322,P=0.012)相关。结论STC2 mRNA和STC2蛋白在子宫内膜癌肿瘤组织中的表达显著高于癌旁组织;STC2表达与子宫内膜癌远处转移相关。
Objective To discuss the expression of STC2 in endometrial carcinoma and the relationship with pathology factors in diagnosis.Methods Fifty patients with endometrial carcinoma were chosen to detect the expression of STC2 mRNA and protein by semi⁃quantitative RT⁃PCR and Western blot.Relationship with pathology factors was analyzed.Results In 50 cases of endometrial cancer,the relative expression of STC2 mRNA was 2.45±0.27,which was significantly higher than that of adjacent tissues 1.19±0.13(t=28.5,P=0.0034).The relative expression of STC2 protein was 1.33±0.27,which was significantly higher than that of adjacent tissues(0.28±0.05)(t=26.4,P=0.0266).STC2 expression was not significantly related to age and pathological classification(χ2=0.028,P=0.743),but was significantly related to FIGO staging(χ2=10.118,P=0.036),pathological differentiation degree(χ2=11.184,P=0.033)and lymph node metastasis(χ2=14.322,P=0.012).Conclusion Expressions of STC2 mRNA and protein in endometrial carcinoma tumor tissues are significantly higher than those of para⁃carcinoma tissue.Expression of STC2 is relevant to distant metastasis of endometrial carcinoma.
作者
付长红
陆晓媛
FU Changhong;LU Xiaoyuan(Department of Obsterics and Gynecology,Affiliated Hospital of Xuzhou Medical University,Xuzhou Jiangsu 221001,China;Department of Gynecology,Zaozhuang Municipal Hospital,Zaozhuang,Shandong 277101,China)
出处
《安徽医药》
CAS
2020年第1期144-146,共3页
Anhui Medical and Pharmaceutical Journal
关键词
子宫内膜肿瘤
淋巴转移
肿瘤侵润
因果律
斯钙素⁃2
Endometrial neoplasms
Lymphatic metastasis
Neoplasm invasiveness
Causality
Stanniocalcin⁃2
