摘要
目的:探讨25羟维生素D[25(OH)D]水平与慢性肾脏病(CKD)患者肾性贫血及血管钙化的相关性。方法:选取2016年3月至2018年3月安徽医科大学附属阜阳医院收治的126例CKD患者,肾性贫血及血管钙化患者68例为研究组,其余58例为对照组。同时选取同期健康者40例作为健康组。检测各组血清25(OH)D、血红蛋白、促红细胞生成素(EPO)、血清铁蛋白、血钙、血磷、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)水平。分析25(OH)D与各项生化指标间的关系,并采用受试者工作特征(ROC)曲线分析25(OH)D对血管钙化和肾性贫血的诊断价值。结果:健康组与对照组血清25(OH)D水平比较无明显差异(P>0.05),研究组血清25(OH)D水平显著低于对照组(P<0.05)。3组血钙、血磷、LDL-C和HDL-C比较均无明显差异(均P>0.05)。研究组25(OH)D和血红蛋白水平均显著低于对照组和健康组,而EPO和血清铁蛋白显著高于对照组和健康组(均P<0.05)。研究组血清25(OH)D与血红蛋白呈正相关关系,与EPO和铁蛋白呈负相关关系(均P<0.05),而与血钙、血磷、LDL-C和HDL-C水平无明显相关关系(均P>0.05)。血清25(OH)D诊断CKD患者肾性贫血及血管钙化的ROC曲线下面积为0.911,临界值为14 ng/mL。结论:血清25(OH)D水平在CKD合并肾性贫血和血管钙化患者中显著降低,对于肾性贫血及血管钙化有一定的诊断价值。
Objective:To investigate the relationship between 25-hydroxy-vitamin D[25(OH)D]levels and renal anemia and angiosteosis in patients with chronic kidney disease(CKD).Methods:A total of 126 patients with CKD in our hospital from March 2016 to March 2018 were enrolled.Among them,68 patients with renal anemia and vascular calcification were selected as a study group,and other 58 patients were defined as a control group.40 healthy people were selected as a healthy group.The 25(OH)D,hemoglobin,erythropoietin(EPO),ferritin,calcium,phosphorus,low-density lipoprotein(LDL-C)and high-density lipoprotein(HDL-L)levels in serum were detected.The relationship between 25(OH)D and various biochemical indicators as well as the diagnosis value of 25(OH)D for vascular calcification and renal anemia were analyzed.Results:There was no significant difference in serum 25(OH)D level between the healthy group and the control group(P>0.05).The serum 25(OH)D level in the study group was significantly lower than that in the control group(P<0.05).There was no significant difference in serum calcium,phosphorus,LDL-C and HDL-C levels among the three groups(P>0.05).The 25(OH)D and hemoglobin levels in the study group were significantly lower than those in the control group and healthy group,while EPO and ferritin levels were significantly higher(P<0.05).Serum 25(OH)D was positively correlated with hemoglobin and negatively correlated with EPO and ferritin in the study group(P<0.05),but not correlated with serum calcium,phosphorus,LDL-C and HDL-C(P<0.05).The area under the ROC curve of serum 25(OH)D was 0.911 with a cutoff value of 14 ng/mL.Conclusion:The serum 25(OH)D in CKD patients with renal anemia and vascular calcification is significantly reduced,and it has certain diagnostic value for renal anemia and vascular calcification.
作者
邓启磊
王娟
邢蓓蓓
赵倩文
于源
Deng Qilei;Wang Juan;Xing Beibei;Zhao Qianwen;Yu Yuan(Fuyang Hospital of Anhui Medical University,Fuyang 236000,China;The People's Hospital ofTaihe County,Anhui Province,Taihe 236600,China)
出处
《广西医科大学学报》
CAS
2019年第12期1955-1958,共4页
Journal of Guangxi Medical University
