摘要
目的通过单中心研究评估不同疾病阶段糖尿病肾病(DKD)患者维生素D缺乏的患病率,同时探索导致DKD患者出现维生素D缺乏的潜在的危险因素及其相关性。方法纳入437名不同糖尿病肾病分期的患者及100名体检人员作为健康对照组,对比两组25-羟基维生素D(25[OH]D)水平。根据25[OH]D水平分组,进行分析对比并进一步探究25[OH]D缺乏的独立风险因素。结果糖尿病肾病各期患者较健康对照组25[OH]D均有降低,BUN每升高1mmol/L,其25[OH]D缺乏的风险较前提高了近118%;TC每增高1mmol/L其患25[OH]D缺乏的风险则会提高近30%;高脂血症与25[OH]D缺乏的发生呈正相关,TG每增高1mmol/L,其发生25[OH]D缺乏的发生率增高近67%;HbA1c每升高1%其发生25[OH]D缺乏的风险增加近60%。eGFR每降低1mL/min/1.73m2其25[OH]D缺乏的发生率升高97.2%。结论血清25[OH]D水平有可能成为糖尿病肾病疾病进展情况的有力的预测因子。
Objective To evaluate the prevalence of vitamin D deficiency in patients with diabetic nephropathy(DKD)of different disease stages and the clinicopathological characteristics of patients with DKD at different stages,and to explore the potential risk factors leading to vitamin D deficiency in patients with DKD and their correlation.Methods In this study,437 patients with different stages of diabetic nephropathy and 100 physical examination personnel were included as healthy control group,and the 25-hydroxyvitamin D(25[OH]D)levels were compared between the two groups.According to the 25[OH]D level classification,the normal group(n=158)and the 25[OH]D level deficiency group(n=379)were analyzed and compared to further explore the independent risk factors of 25[OH]D deficiency.Results The 25[OH]D of diabetic nephropathy patients in all stages was lower than that of healthy control group.The risk of 25[OH]D deficiency was increased by nearly 118%for each increase of BUN 1mmol/L.The risk of 25[OH]D deficiency increased by nearly 30%for every 1mmol/L increase in TC.The incidence of 25[OH]D deficiency was positively correlated with hyperlipidemia,and the incidence of 25[OH]D deficiency was increased by nearly 67%for every 1mmol/L increase of TG.For every 1%increase in HbA1c,the risk of developing 25[OH]D deficiency increased by nearly 60%.The incidence of 25[OH]D deficiency increased by 97.2%for every 1mL/min/1.73m2 decrease in eGFR.Conclusion Serum 25[OH]D level may be a powerful predictor of the progression of diabetic nephropathy.
作者
哈晓文
姜鸿
HA Xiaowen;JIANG Hong(Division of Nephrology,Department of Internal Medicine,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)
出处
《新疆医学》
2024年第5期509-513,565,共6页
Xinjiang Medical Journal
基金
新疆维吾尔自治区人民医院院内基金(项目编号:20220226)
