期刊文献+

广泛性焦虑症患者情感调控环路脑区18F-FDG动态摄取及代谢特征 被引量:2

The 18F-FDG dynamic uptake and metabolism study of emotional regulationloop in the generalized anxiety disorder
下载PDF
导出
摘要 目的:通过PET显像手段观察18F-氟代脱氧葡萄糖(18F-FDG)在广泛性焦虑症(generalized anxiety disorder,GAD)患者情感调控环路多脑区的摄取及代谢情况,探讨GAD患者脑功能异常机制。方法:临床收集20例GAD患者及20例健康受试者,行动态PET-CT扫描,采集18F-FDG全脑摄取及代谢数据,通过图像融合及半定量分析法测量情感调控环路多脑区150 min共11个时间点的最高标准摄取值(SUVmax)及动态摄取、代谢变化规律。结果:与健康对照组相比,GAD患者双侧前额叶皮层摄取峰值和达峰前平均摄取速率明显降低(P <0. 05),达峰后平均代谢速率明显增高(P <0. 05);左侧纹状体及左侧海马摄取峰值、达峰前平均摄取速率和达峰后平均代谢速率均明显降低(P <0. 05);左侧丘脑摄取峰值、达峰前平均摄取速率和达峰后平均代谢速率均明显增高(P <0. 05);右侧丘脑摄取峰值和达峰前平均摄取速率明显增高(P <0. 05),达峰后平均代谢速率变化无明显差异;右侧纹状体和右侧海马3个指标无明显变化。结论:GAD患者情感调控环路多个脑区存在18F-FDG摄取及代谢障碍,其摄取峰值及速率异常可能与GAD发病有关。 Objective: To observe the uptake and metabolism of 18F-Fluorodeoxyglucose (18F-FDG) in various brain regions of the emotional regulationloop in generalized anxiety disorder (GAD) based on the PET,and the mechanism of brain dysfunction in GAD was studied. Methods: Dynamic PET-CT scanning was performed on 20 GAD patients and 20 healthy subjects. 18F-FDG whole-brain uptake and metabolism data were collected. SUVmax, dynamic uptake and metabolism changes of each brain structure at 11 time points in 150 mins were measured based on image fusion and semi-quantitative analysis. Results: Compared to the control group, there were less and slower uptake of 18F-FDG, faster metabolism in the bilateral prefrontal cortex in GAD group(P<0.05).There were less, slower uptake of 18F-FDG and slower metabolism in the left striatum and left hippocampus in GAD group(P<0.05). There were more, faster uptake of 18F-FDG and faster metabolism in the left thalamus in GAD group(P<0.05).There were more and faster uptake of 18F-FDG in the right thalamus(P<0.05), but no significant metabolism change in GAD group. The 3 indicators in right striatum and right hippocampus had no significant change in GAD group.Conclusion: There are 18F-FDG uptake and metabolism disorder of multiple brain structures of this loop in GAD, and its abnormal uptake peak, rate of uptake and rate of metabolism may be involved in the GAD.
作者 石俊 李燕 朱彦 刘文新 李月峰 丁宇晨 张书玉 SHI Jun;LI Yan;ZHU Yan;LIU Wen-xin;LI Yue-feng;DING Yu-chen;ZHANG Shu-yu(Department of Medical Imaging , Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001;Department of Ultrasonic , the Fourth Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu 212001;School of Medicine, Jiangsu University,Zhenjiang Jiangsu 212013, China)
出处 《江苏大学学报(医学版)》 CAS 2019年第6期494-498,共5页 Journal of Jiangsu University:Medicine Edition
关键词 广泛性焦虑症 情感调节环路 正电子发射断层显像计算机体层摄影术 最大标准摄取值 generalized anxiety disorder emotional regulationloop PET-CT maximum standardized uptake value
  • 相关文献

同被引文献24

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部