摘要
背景:焦虑障碍是精神科最常见的疾病之一,但是25%的患者对药物,心理及认知行为治疗等无反应。重复经颅磁刺激目前已广泛用于精神分裂症,抑郁症,焦虑症,强迫症等精神障碍的治疗,并取得了满意的疗效。目标:探讨文拉法辛联合重复经颅磁刺激治疗广泛性焦虑症的疗效和安全性。方法:70例广泛性焦虑症患者随机分为两组,研究组口服文拉法辛及劳拉西泮联合重复经颅磁刺激治疗,对照组单用文拉法辛劳拉西泮治疗,连续观察6周。与治疗前后采用汉密尔顿焦虑量表及临床疗效总评量表-病情严重程度分量表评定临床疗效,副反应量表评定不良反应。结果:治疗后两组均能改善广泛性焦虑患者的临床症状,但是药物联合rT MS治疗组疗效要优于单纯药物治疗组。
Background： Generalized Anxiety Disorder（GAD） is one of common disorder in psychiatric department. However, about 25% patients are unresponsive to both drug and psychotherapy such as cognitive behaviour therapy. The repetitive transcranial magnet stimulation（rT MS） is widely applied in treatment of schizophrenia, major depression disorder, generalized anxiety disorder, obsessive-compulsive disorder and other types of mental disorders, and has a promising effect.Aim： To evaluate the curative effect and safety using venlafaxine combined with repetitive transcranial magnet stimulation in treatment of generalized anxiety disorder.Methods： Seventy patients with a diagnosis of GAD were recruited and randomly divided into two groups. The study group received oral administration of venlafaxine and lorazepam and stimulation of repetitive transcranial magnet. The control group only received venlafaxine and lorazepam. After 6-week observation, Hamilton Anxiety Scale（HAMA） and Clinical Global Impression Severity（CGI-SI） were performed to evaluate the effect of treatment, and Treatment Emergent Symptoms Scale to assess the side effects.Results： While the symptoms of GAD were improved in both groups after 6-week therapy, the efficacy of the drug-rT MS combined group is superior to another.Conclusions： The findings of this study indicate that repetitive transcranial magnet stimulation combined with venlafaxine has a significant therapeutic effect treating GAD.
出处
《上海精神医学》
CSCD
2016年第4期212-217,共6页
Shanghai Archives of Psychiatry
基金
supported by the National Nature Science Fund of China(grant number:81360211)
