摘要
目的探讨Lauren分型为混合型的进展期胃癌接受术后放化疗的近期疗效和远期疗效。方法回顾性分析2014年6月至2015年6月在江南大学附属医院行D 2根治术的Lauren分型为混合型进展期胃癌患者50例,术后XELOX化疗2个周期,后同期放化疗,放疗后辅助化疗XELOX4个周期,放疗采用IMRT,DT为45Gy/25次。评价不良反应,随访患者的3年总生存率(OS)和3年无瘤生存率(DFS)。结果50例混合型胃癌患者中位年龄为57岁(30~75岁),男女比例1.5∶1,3年OS率为60.0%,3年的DFS率为52.0%。Cox回归单因素分析显示N分期和淋巴结阳性率是影响OS和DFS的预后因素。最常见1~2级不良反应为血液学毒性、胃肠道反应、手足口综合征,6例3级的恶心反应,3例3级的手足口综合征,1例4级白细胞减少,1例4级贫血,2例4级食欲不振。结论Lauren分型为混合型的进展期胃癌术后放化疗疗效尚可,不良反应可耐受,安全性良好。
Objective To explore the short-term and long-term effects of postoperative radiotherapy and chemotherapy for Lauren s mixed type advanced gastric cancer.Methods From June 2014 to June 2015,50 patients with mixed advanced gastric cancer were analyzed retrospectively.After operation,the patient received XELOX chemotherapy for 2 cycles,followed by radiotherapy and chemotherapy at the same time,followed by adjuvant chemotherapy for XELOX 4 cycles.The radiotherapy was IMRT and DT was 45Gy/25 times.The adverse reactions were evaluated.The overall 3-year survival rate(OS)and 3-year tumor free survival rate(DFS)were evaluated.Results The median age of 50 patients with mixed gastric cancer was 57 years(30-75 years),the ratio of male to female was 1.5∶1,the 3-year OS rate was 60.0%,and the 3-year DFS rate was 52.0%.Cox regression univariate analysis showed that N stage and lymph node positive rate were the prognostic factors of OS and DFS.The most common level 1-2 adverse reactions were hematological toxicity,gastrointestinal reaction,hand foot mouth syndrome.There were 6 cases of grade 3 nausea,3 cases of grade 3 hand foot mouth syndrome,1 case of grade 4 leukopenia,1 case of grade 4 anemia and 2 cases of grade 4 anorexia.Conclusion Lauren s mixed type of advanced gastric cancer is safe and tolerable.
作者
陈建江
赵于天
张晓军
杨开华
吴刚
徐钰
CHEN Jianjiang;ZHAO Yutian;ZHANG Xiaojun;YANG Kaihua;WU Gang;XU Yu(Department of Radiation Oncology,Affiliated Hospital of Jiangnan University(Wuxi NO.4 People’s Hospital),Wuxi 214062,China)
出处
《临床肿瘤学杂志》
CAS
北大核心
2019年第12期1130-1133,共4页
Chinese Clinical Oncology
关键词
进展期胃癌
术后放化疗
Lauren分型
混合型
Advanced gastric cancer
Postoperative chemoradiotherapy
Lauren classification
Mixed type
