摘要
目的:利用光学相干断层扫描血管成像(OCTA)检测不同中医证型POAG患者视盘及黄斑血流变化,并分析其与POAG视神经损害的相关性。方法:将POAG患者103例103眼依据中医证型分类,比较不同中医证型OCTA测得的视盘血管密度、黄斑区血管密度、视乳头旁视网膜神经纤维层(pRNFL)厚度、神经节细胞复合体(GCC)厚度,并对OCTA血管密度各参数与视野平均缺损(MD)值进行相关性分析。结果:POAG患者三组中医证型最佳矫正视力(BCVA,LogMAR)、眼压、病程均有差异(F=29.671、13.05、108.60,均P<0.01)。三组中医证型的黄斑(上、颞、下、鼻)四个方位GCC厚度、视盘血管密度、黄斑血管密度均有差异(P<0.01)。三组中医证型的视盘上、颞、下侧RNFL厚度均有差异(P<0.01)。视盘血管密度、黄斑血管密度与视野MD值均呈线性正相关(r=0.591、0.402,均P<0.01)。结论:OCTA作为不同证型POAG患者的视盘血管密度的量化评价指标,为POAG中西医结合治疗提供了有力的客观理论依据。
AIM:The changes of optic disc and macular blood flow in POAG patients with different symptom types of traditional chinese medicine(TCM)were detected by OCTA,and the correlation between them and optic nerve damage was analyzed.METHODS:Totally 103 eyes of 103 POAG patients were classified according to the different symptom types of TCM.The vascular density of optic disc,the vascular density of macular area,the thickness of peripapillary retinal nerve fiber layer(pRNFL),and the thickness of ganglia cell complex(GCC)were collected by OCTA,and then the differences among them were analyzed.The correlation between the blood flow parameters and visual field of mean deviation(MD)was also analyzed.RESULTS:There were significant differences in best corrected visual acuity(BCVA),intraocular pressure(IOP)and course of disease among the three groups of POAG patients(F=29.671,13.05,108.60;all P<0.01).The differences in macular GCC thickness,pRNFL thickness,optic disc vascular density and macular vascular density in different regions among the three groups were significant(P<0.01).Linear positive correlation were found between optic disc vascular density,macular vascular density and visual field MD(r=0.591,0.402,all P<0.001).CONCLUSION:OCTA can be used as an evaluation index for POAG patients with different symptom types,and it can provide a strong objective theoretical basis for the treatment of POAG.
作者
车慧欣
何伟
徐玲
Hui-Xin Che;Wei He;Ling Xu(Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning Province,China;Liaoning He University,He Eye Specialist Hospital,Shenyang 110034,Liaoning Province,China)
出处
《国际眼科杂志》
CAS
北大核心
2020年第1期119-123,共5页
International Eye Science
基金
辽宁省自然科学基金资助(No.2014022022)
辽宁省自然科学基金重点资助(No.20170540399)
辽宁省卫计委临床能力建设项目(No.LNCCCD31-2015)~~
