摘要
目的研究精神分裂症患者实施阿立哌唑与小剂量氯氮平联合治疗的临床效果及不良反应发生率影响。方法选择2013年4月至2018年4月本院收治的精神分裂症患者291例为研究对象,采用奇偶法分为实验组146例与参照组145例。其中参照组采用阿立哌唑治疗,实验组行阿立哌唑与小剂量氯氮平联合治疗,对比两组患者治疗前后相关评分、不良反应及临床效果。结果治疗前两组患者相关评分比较差异无统计学意义,两组不良反应发生率(8.22%vs.8.97%),差异无统计学意义。与参照组相比,治疗后实验组PANSS评分较低,实验组生活质量评分高于参照组,实验组精神分裂症临床效果为98.63%,高于参照组的91.72%,差异有统计学意义(P<0.05)。结论精神分裂症患者采用阿立哌唑与小剂量氯氮平联合治疗的效果显著,且药物不良反应相对较低,值得临床推广。
Objective To study the clinical effects and adverse reactions of aripiprazole combined with low-dose clozapine in patients with schizophrenia.Methods A total of 291 patients with schizophrenia in our hospital were enrolled during April 2013 to April 2018.They were divided into experimental group(146 cases)and reference group(145 cases)by parity method.The reference group was treated with aripiprazole.The experimental group was treated with aripiprazole in combination with low-dose clozapine.The scores,adverse reactions and clinical effects of the two groups were compared before and after treatment.Results There was no difference in the scores of the two groups before treatment.There was no difference in the incidence of adverse drug reactions(8.22%vs.8.97%)between the two groups.Compared with the reference group,the PANSS score of the experimental group was lower after treatment,and the quality of life score of the experimental group was higher than that of the reference group.The clinical effect of schizophrenia in the experimental group(98.63%)was higher than that of the reference group(91.72%).There was significant difference between the two group(P<0.05).Conclusion The combination of aripiprazole and low-dose clozapine in patients with schizophrenia is effective,and the adverse drug reactions are relatively low,which should be clinically promoted.
作者
杨柳
肖湘凌
Yang Liu;Xiao Xiangling(Department of Medical Equipment,Chaoyang Kangning Hospital,Chaoyang,Liaoning,122000,China)
出处
《当代医学》
2020年第2期77-79,共3页
Contemporary Medicine
