摘要
目的探究游离前列腺特异性抗原(fPSA)、总前列腺特异性抗原(tPSA)和fPSA/tPSA比值在前列腺癌和良性前列腺增生老年患者中的诊断价值。方法采用罗氏e411电化学发光免疫定量分析仪、Free PSA及Total PSA试剂盒检测前列腺癌(PCa)组(45例)、前列腺增生(BPH)组(89例)、正常对照组(194例)血清tPSA、fPSA的含量,并计算fPSA/tPSA比值。结果PCa组和BPH组的fPSA值和tPSA值均高于正常对照组,PCa组fPSA/tPSA比值低于正常对照组(P均<0.001);PCa组的fPSA值和tPSA值均高于BPH组,fPSA/tPSA比值低于BPH组(P均<0.001)。结论tPSA、fPSA和fPSA/tPSA比值可以区分老年男性前列腺癌和良性前列腺增生。
Objective To study the diagnostic value of free prostate specific antigen(fPSA),total prostate specific antigen(tPSA)and fPSA/tPSA ratio in 60-90-year-old men with prostate cancer or benign prostatic hyperplasia.Methods The serum levels of tPSA and fPSA in prostate cancer(PCa)group(45 cases),benign prostatic hyperplasia(BPH)group(89 cases)and normal control group(194 cases)were detected by Roche e411 electrochemiluminescence immunoassay analyzer.fPSA,tPSA and the fPSA/tPSA ratio was calculated.Results Results showed that the values of fPSA and tPSA in PCa and BPH groups were higher than those in normal control group,the values of fPSA and tPSA in PCa group were higher than those in BPH group(P all<0.001).The value of fPSA/tPSA in PCa group was lower than those in normal control group,the value of fPSA/tPSA in PCa group was lower than those in BPH group(P all<0.001).Conclusion The valce of fPSA,tPSAand fPSA/tPSA can distinguish prostate cancer or benign prostatic hyperplasia.
作者
宋佳卉
孙萍
SONG Jiahui;SUN Ping(Ningxia Medical University,Yinchuan750004,China;Third People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan750004,China)
出处
《宁夏医科大学学报》
2019年第9期954-956,共3页
Journal of Ningxia Medical University
关键词
前列腺癌
前列腺增生
游离前列腺特异性抗原
总前列腺特异性抗原
prostate cancer
benign prostatic hyperplasia
free prostate specific antigen
total prostate specific antigen
