摘要
目的通过测定60岁以上男性体检人群血清中总前列腺特异性抗原(tPSA)及游离前列腺特异性抗原(fPSA)含量,探讨游离前列腺特异性抗原(fPSA)与总前列腺特异性抗原(tPSA)比率(fPSA/tPSA即%fPSA)在鉴别诊断前列腺癌与良性前列腺增生时的重要意义。方法选取2019年3至9月60岁以上(上海常住人口)男性体检人群4105例,采用罗氏cobase411进行检测tPSA及fPSA,并求得%fPSA值。结果根据体检人群血清tPSA、fPSA及%fPSA检测结果,结合B超和其他检查,区分为前列腺癌患者、良性前列腺增生患者和健康人群三组,与健康人群组比较,前列腺良性增生组和前列腺癌组%fPSA差异有统计学意义(P<0.05)。结论对60岁以上男性进行%fPSA检测可提高前列腺癌检出率,%fPSA值结合临床情况为前列腺良性增生与前列腺癌的鉴别诊断提供了重要依据。
Objective Through the determination of total prostate specific antigen(tPSA)and free prostate specific antigen(fPSA)in the serum of men over 60 years of age,to investigate the significance of the ratio of free prostate-specific antigen(fPSA)to total prostate-specific antigen(tPSA)(fPSA/tPSA,or%fPSA)in differentiating prostate cancer from benign prostatic hyperplasia.Methods From March to September 2019,4105 men over the age of 60(Shanghai resident population)were examined.Roche cobase411 was used to test tPSA and fPSA,and the value of%fPSA was obtained.Results According to the results of the serum tPSA,fPSA,and%fPSA tests in the physical examination population,combined with B ultrasound and other tests,they were divided into three groups:prostate cancer patients,benign prostatic hyperplasia patients,and healthy people,and compared with healthy groups.The difference between the benign prostatic hyperplasia group and the prostate cancer group%fPSA was statistically significant(P<0.05).Conclusion The detection rate of prostate cancer can be improved by the detection of%t PSA in men over 60 years of age.The%t PSA value combined with clinical conditions provides an important basis for the differential diagnosis of benign prostatic hyperplasia and prostate cancer.
作者
孙斐
褚登峰
蔡则毅
SUN Fei;CHU Dengfeng;CAI Zeyi(Department of Clinical Laboratory,the Fengpu Community Health Service Center,Shanghai 201401,China)
出处
《检验医学与临床》
CAS
2019年第S02期92-94,共3页
Laboratory Medicine and Clinic
关键词
体检人群
前列腺特异性抗原
前列腺癌
良性前列腺增生
examination crowd
prostate specific antigen
prostate cancer
benign prostatic hyperplasia
