摘要
目的研究B族链球菌感染(GBS)孕妇应用抗菌药物干预对分娩方式和母婴安全性的影响。方法将2017年1月-2017年12月于新郑市人民医院收治的确诊的GBS感染孕妇164例纳入本次研究,根据分娩阶段是否接受抗感染治疗分为临床干预组(82例)和感染组(82例),并选择同期产科门诊建档产检的90例健康产妇为健康对照。分析所有孕妇凝血功能、分娩方式和母婴结局差异。结果GBS感染患者中临床干预组和感染组在分娩方式中剖宫产、顺产及产钳助产均明显差异(P<0.05);两组患者妊娠结局中早产、宫腔感染、胎膜早破、胎儿窘迫的发生情况相比差异显著(P<0.05);GBS感染患者中临床干预组新生儿并发症中发生新生儿肺炎、新生儿窒息、病理性黄疸、败血症及脑膜炎发生率均明显低于感染组(P<0.05);GBS感染组孕妇PT、APTT、INR均明显低于其余两组(P<0.05);FIB表达明显高于其余两组(P<0.05)。结论GBS可改变孕妇凝血功能并造成分娩方式、妊娠结局、新生儿并发症等方面的影响,及时合理应用抗生素可有效降低母婴不良结局发生率,值得临床应用。
Objective To study the effect of antibiotic intervention on delivery mode and safety of maternal and infant in pregnant women with group B streptococcal infection(GBS).Methods 164 pregnant women who were infected by GBS admitted to Xinzheng People's Hospital from January 2017 to December 2017 were enrolled in this study and were divided into the clinical intervention group(82 cases)and the infection group(82 cases)according to whether they received anti-infection treatment during delivery or not.And 90 healthy pregnant women with documented birth examination in the obstetrics clinic during the same period were selected as healthy controls.Blood coagulation function,delivery mode and maternal and infant outcomes were analyzed in all pregnant women.Results Among patients with GBS infection,there were significant differences between the clinical intervention group and the infection group in delivery mode in cesarean section,vaginal delivery and forceps midwifery(P<0.05).There were significant differences in the incidence of premature delivery,uterine infection,premature rupture of membranes and fetal distress between the two groups(P<0.05).The incidence of neonatal pneumonia,neonatal asphyxia,pathological jaundice,sepsis and meningitis in the clinical intervention group of patients with GBS infection was significantly lower than that in the infection group(P<0.05).PT,APTT and INR of pregnant women in the GBS infected group were significantly lower than those in the other two groups(P<0.05).FIB expression was significantly higher than that of the other two groups(P<0.05).Conclusion GBS can change the coagulation function of pregnant women and make effects on delivery mode,pregnancy outcome,neonatal complications,etc.Timely and reasonablely applying of antibiotics can effectively reduce the incidence rate of adverse outcomes of mothers and infants,which is worthy of clinical application.
作者
吴冬青
WU Dongqing(Department of Clinical Laboratory,Xinzheng People's Hospital,Xinzheng Henan 451100,China)
出处
《临床研究》
2019年第12期137-139,共3页
Clinical Research
