摘要
目的探讨酪酸梭菌活菌散联合蓝光照射治疗新生儿病理性黄疸的临床效果。方法选取2018年1月~2019年3月本院接收的84例病理性黄疸新生儿为研究对象,随机分为对照组和实验组,各42例,对照组给予蓝光照射治疗,实验组在此基础上联合使用酪酸梭菌活菌散治疗,比较两组治疗效果、症状消失时间、住院时间、血清总胆红素水平变化、免疫功能及不良反应发生情况。结果实验组总有效率高于对照组,差异有统计学意义(P<0.05);实验组黄疸消失时间、住院时间均短于对照组,差异有统计学意义(P<0.05);治疗第3、6天及结束后,两组血清胆红素水平均降低,且实验组低于对照组,差异有统计学意义(P<0.05);治疗后两组CD3^+、CD4^+、CD4^+/CD8^+指标均升高,且实验组高于对照组,差异有统计学意义(P<0.05)。实验组不良反应发生率低于对照组,但差异无统计学意义(P>0.05)。结论酪酸梭菌活菌散联合蓝光照射治疗新生儿病理性黄疸效果较好,有助于降低患儿血清胆红素水平,改善其临床症状及机体免疫功能,不增加不良反应,安全性较高。
Objective To investigate the clinical effect of Clostridium butyricum live bacteria powder combined with blue light irradiation on neonatal pathological jaundice.Methods A total of 84 neonatal patients with pathological jaundice received in our hospital from January 2018 to March 2019 were randomly selected into the control group and the experimental group,each with 42 patients.The control group was treated with blue light irradiation.The experimental group was here.Based on the combined use of Clostridium butyricum live bacteria powder,the treatment effects,time to disappear symptoms,length of hospital stay,changes in serum total bilirubin levels,immune function and adverse reactions were compared between the two groups.Results The total effective rate in the experimental group was higher than that in the control group,the differences were statistically significant(P<0.05).The jaundice disappearance time and hospital stay in the experimental group were shorter than those in the control group,the differences were statistically significant(P<0.05).On the 3rd and 6th days after treatment,serum bilirubin levels in the two groups decreased,and the experimental group was lower than the control group,the difference was statistically significant(P<0.05);After treatment,the CD3^+,CD4^+,and CD4^+/CD8^+indexes were increased in the two groups,and the experimental group was higher than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was lower than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion Clostridium butyricum living bacteria powder combined with blue light irradiation is effective in treating neonatal pathological jaundice,and it is helpful to reduce the serum bilirubin level of children,improve its clinical symptoms and immune function,and increase safety without increasing adverse reactions.
作者
肖文
XIAO Wen(Department of Neonatal,Yichun Maternal and Child Health Hospital,Yichun 336000,Jiangxi,China)
出处
《医学信息》
2019年第24期140-142,共3页
Journal of Medical Information
关键词
新生儿病理性黄疸
酪酸梭菌活菌散
蓝光照射
免疫功能
Neonatal pathological jaundice
Clostridium butyricum live bacteria powder
Blue light irradiation
Immune function
