摘要
目的探究高龄孕妇妊娠中期唐氏筛查的临床价值。方法选择2016年9月至2018年6月本院收治的接受唐氏综合征筛查的孕妇1 268例作为研究对象,将筛查的孕妇按照年龄分成高龄组和对照组,每组634例,高龄组年龄≥35岁,对照组孕妇年龄20~35岁。对两组孕妇进行唐氏筛查、羊水穿刺细胞培养检查,并对检查结果进行统计分析。结果高龄组孕妇唐氏筛查的阳性率为15.30%,明显高于对照组,差异具有统计学意义(P<0.05);高龄组唐氏儿的所占比例、染色体核型异常发生率、唐氏筛查软件对唐氏儿的检出率等均明显高于对照组,差异均具有统计学意义(P<0.05);高龄组不良妊娠结局发生率明显高于对照组,差异均具有统计学意义(P<0.05)。结论孕中期对高龄孕妇实施唐氏综合症血清检查,能够准确反映其存在的高风险指征。并依据检查结果,对妊娠结局实施合理干预,改善妊娠结局。
Objective To explore the clinical value of Down’ s screening in the second trimester of pregnant women. Methods A total of 1 268 pregnant women who were screened for Down’ s syndrome admitted to our hospital from September 2016 to June 2018 were enrolled. The pregnant women who were screened were divided into the older group and the control group according to age, with 634 patients in each group. The age of theelderly group was ≥35 years old, and the age of the control group was 20-35 years old. Down’ s screening, amniocentesis cell culture examination were performed on the two groups of pregnant women, and the results of the examination were statistically analyzed. Results The positive rate of Down’ s screening in pregnant women was 15.30%, which was significantly higher than that in the control group. The difference was statistically significant(P<0.05). The proportion of Down’ s children in the elderly group, the incidence of karyotype abnormalities. The detection rate of Down’ s screening software was significantly higher than that of the control group, and the difference was statistically significant(P<0.05). The incidence of adverse pregnancy outcome in the old age group was significantly higher than that of the control group, and the difference was statistically significant(P<0.05). Conclusion The implementation of Down’ s syndrome serum test in pregnant women in the second trimester can accurately reflect the highrisk indications of their presence. According to the results of the examination, reasonable intervention was implemented on the pregnancy outcome to improve the pregnancy outcome.
作者
赵娜
胡凯
闵文光
Zhao Na;Hu Kai;Min Wenguang(Department of Clinical Laboratory,Second People's Hospital of Jingdezhen,Jingdezhen,Jiangxi,333000,China;Jingdezhen City Center for Disease Control and Prevention,Jiangxi Province,Jingdezhen,Jiangxi,333000,China)
出处
《当代医学》
2019年第34期25-27,共3页
Contemporary Medicine
基金
江西省卫计委科技计划项（20177189)
关键词
高龄孕妇
唐氏筛查
妊娠中期
临床研究
Elderly pregnant women
Down’ s screening
Second trimester pregnancy
Clinical study
