摘要
高迁移率族蛋白B1(HMGB1)是一种广泛存在于真核细胞内的高度保守的核蛋白,释放到核外或细胞外时参与多种疾病的病理过程,包括脓毒症、恶性肿瘤、慢性阻塞性肺病、自身免疫性疾病、动脉粥样硬化和心血管疾病等。大量研究证实:心脏炎症反应是多种心脏疾病发生的重要病理机制,而HMGB1作为一种晚期炎症介质在心肌炎、心肌缺血再灌注损伤、心肌梗死和心力衰竭等心脏疾病中发挥关键作用。现就HMGB1在心脏炎症反应性疾病中的作用进行综述。
High-mobility group box-1(HMGB1)is a highly conserved nuclear protein widely distributed in eukaryotic cells.It is involved in the pathological processes of various diseases when released outside the nucleus or cells.These include sepsis,malignant tumors,chronic obstructive pulmonary disease,autoimmune diseases,atherosclerosis and cardiovascular disease.Numerous studies have confirmed that cardiac inflammatory response is an important pathological mechanism for the development of a variety of heart diseases,and HMGB1,as a late inflammatory mediator,plays a key role in heart disease such as myocarditis,myocardial ischemia-reperfusion injury,myocardial infarction and heart failure.Therefore,this article reviews the role of HMGB1 in inflammatory heart diseases.
作者
陈丰
苏强
朱继金
CHEN Feng;SU Qiang;ZHU Jijin(Guangxi Medical University Graduate School,Nanning 530021,Guangxi,China;Department of Emergency,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China)
出处
《心血管病学进展》
CAS
2019年第8期1111-1114,共4页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(81600283)
广西自然科学基金(2017GXNSFAA198069)
关键词
高迁移率族蛋白B1
心脏炎症反应
心肌炎
缺血再灌注损伤
心肌梗死
心力衰竭
High-mobility group box-1
Cardiac inflammatory response
Myocarditis
Ischemia-reperfusion injury
Myocardial infarction
Heart failure
