摘要
目的:分析胃癌患者血清微小核糖核酸-183(miR-183)、选择素-E(E-selectin)、α-1-微球蛋白/胰蛋白酶抑制剂前体(AMBP)的变化及与临床病理的关系。方法:选择我院2018年1月至2019年1月收治的96例胃癌患者,同期选择门诊健康体检者30例。比较胃癌组和对照组血清miR-183、E-selectin、AMBP水平,并分析以上指标和临床病理的联系,及对胃癌诊断的预测价值。结果:胃癌组血清miR-183、E-selectin、AMBP水平高于对照组,比较有统计学差异(P<0.05)。miR-183、E-selectin、AMBP水平在不同TNMⅢ~Ⅳ期、有淋巴结转移及浸润深度T3~T4者血清miR-183、E-selectin、AMBP均分别高于TNMⅠ~Ⅱ期、无淋巴结转移及浸润深度T1~T2者,比较有统计学差异(P<0.05)。miR-183的曲线下面积为0.687,敏感度和特异度分别为0.833和0.625;E-selectin曲线下面积为0.854,敏感度和特异度分别为0.831和0.829;AMBP曲线下面积为0.752,敏感度和特异度分别为0.867和0.635;联合测定曲线下面积为0.908,敏感度和特异度分别为0.900和0.843。结论:血清mi-183、E-selectin及AMBP水平和胃癌临床病理相关,且可利于胃癌的诊断,联合监测能够弥补单项指标的不足,在临床有较高的应用价值。
Objective: To analyze the changes of serum Microrna-183(mir-183), E-selectin and α1-microglobulin/precursor trypsin inhibitor(AMBP) in patients with gastric cancer and their relationship with clinical pathology. Methods: 96 patients with gastric cancer who treated from January 2016 to January 2017 in our hospital and 30 patients with outpatient health examination were selected at the same time. Then serum levels of miR-183, E-selectin and AMBP between the gastric cancer group and the control group were compared, and the correlation between the above indicators and clinical pathology was analyzed, and the predictive value of gastric cancer diagnosis was also analyzed. Results: Serum levels of miR-183, E-selectin and AMBP in gastric cancer group were higher than the control group, there were a statistically significant difference(P<0.05).The levels of miR-183, E-selectin and AMBP in serum of patients with different TNMⅢ-Ⅳ stages, lymph node metastasis and infiltration depth T3-T4 were higher than those of patients with TNM-Ⅱ stages, no lymph node metastasis and infiltration depth T1-T2, with statistical difference(P<0.05). Serum miR-183, E-selectin and AMBP levels showed no difference among different ages, genders, tumor distribution sites, HP infection and tumor differentiation(P>0.05). The area under the curve of miR-183 was 0.687, and the sensitivity and specificity were 0.833 and 0.625; The area under the E-selectin curve was 0.854, and the sensitivity and specificity were 0.831 and 0.829;The area under the AMBP curve was 0.752, and the sensitivity and specificity were 0.867 and 0.635;The area under the curve was 0.908, and the sensitivity and specificity were 0.900 and 0.843. Conclusion: Serum levels of miR-183, E-selectin and AMBP are correlated with the clinical pathology of gastric cancer, it can also facilitate the diagnosis of gastric cancer, combined monitoring can make up for the deficiency of single index and has high clinical application value.
作者
靳枫
余少康
李柱
潘毅贞
王树滨
JIN Feng;YU Shaokang;LI Zhu(Shenzhen Hospital Affiliated to Peking University,Guangdong Shenzhen 518000,China)
出处
《河北医学》
CAS
2019年第12期2094-2098,共5页
Hebei Medicine
基金
国家自然科学基金资助项目,(编号:81602489)
