摘要
背景:研究发现三维有限元分析可用于膝关节生物学研究,但关于股骨内侧髁不同缺损后周围软骨应力变化的研究不多。目的:探讨膝关节股骨内侧髁软骨发生不同缺损前后周围关节软骨应力的变化趋势,为膝关节股骨内侧髁软骨缺损患者提供生物力学数据。方法:选取正常成人1例建立三维数字有限元模型,在Abaques软件中将己划分好网格的模型录入材料力学特性,约束边界条件及在模型上加载载荷,进行有限元结构非线性计算,首先观察正常膝关节软骨半月板在载荷条件下的应力空间分布,然后观察股骨内侧髁软骨发生不同缺损(0,6,8,10,12,14,16,18,20 mm)后周边软骨在载荷条件下的应力空间分布,分析股骨内侧髁软骨缺损时发生在软骨上的应力改变情况。研究方案获得昆明医科大学第一附属医院伦理委员会批准,试验志愿者对试验过程完全知情同意。结果与结论:①成功定义了模型的材料属性、边界条件及载荷的引入,并得出了膝关节内侧髁软骨发生不同直径缺损时关节软骨的应力云图及其应力数据,经统计分析得到,当股骨内侧髁软骨出现10 mm(面积0.78 cm2)和12 mm(面积1.13 cm2)缺损分别为股骨髁和胫骨平台软骨上的应力较无缺损时有显著性变化;②应用三维有限元法计算得出了在膝关节内侧髁的软骨发生不同直径缺损的情况下膝关节软骨的应力变化趋势;③结果表明股骨内髁直径10 mm(面积0.78 cm2)缺损可能是进行软骨修复手术干预的最小直径。
BACKGROUND:Although it has been found in many studies that three-dimensional finite element analysis can be used in the study of knee joint biomechanics,there are few researches on different defect areas of medial condyle cartilage of the femur.OBJECTIVE:To analyze the stress change trend of perimeter articular cartilage before and after the occurrence of different defect areas of medial femoral condyle cartilage,providing biomechanical data for patients with knee medial femoral condyle cartilage defect.METHODS:One normal adult had been selected to establish a three-dimensional finite element model.Material mechanical properties were input to Abaques software with divided grid model.After controlling boundary condition with mechanical load,structural nonlinear finite element was calculated.First,the load stress distribution of knee cartilage and meniscus was observed under normal stress.Articular cartilage stress distribution was observed with load conditions in different defects(0,6,8,10,12,14,16,18 and 20 mm)of medial femoral condyle.The stress changes on the cartilage were analyzed during the defect of medial femoral condyle.This study was approved by the Ethics Committee of First Affiliated Hospital of Kunming Medical University.The volunteer signed the informed consent.RESULTS AND CONCLUSION:(1)Material properties,boundary conditions and the introduction of loads were defined successfully.The stress cloud chart and its stress data were obtained from different diameter defects of cartilage in medial condyle of knee joint.According to statistical analysis,the stress on the femoral condyle and tibial plateau cartilage had significant changes compared with no defects when the medial femoral condyle cartilage had defects of 10 mm(area 0.78 cm2)and 12 mm(area 1.13 cm2).(2)The stress change trend of the cartilage of the medial condyle of the knee joint under the condition of different diameter defects was calculated based on the analysis of the application of three-dimensional finite element method.(3)Results sugge
作者
张叶明
吴迪
张玲
刘敏
余勇
崔杰文
袁炳乾
李青
Zhang Yeming;Wu Di;Zhang Ling;Liu Min;Yu Yong;Cui Jiewen;Yuan Bingqian;Li Qing(Departmentof Orthopedics,First Affiliated Hospital of Kunming Medical University,Yunnan Institute of Orthopedics,Kunming 650000,Yunnan Province,China;People’s Hospital of Xiangyun,Dali 672100,Yunnan Province,China;Zhaotong Hospital of Traditional Chinese Medicine,Zhaotong 657000,Yunnan Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第12期1911-1916,共6页
Chinese Journal of Tissue Engineering Research
关键词
股骨内侧髁软骨
不同缺损面积
周围软骨
应力
三维有限元分析
medial condylar cartilage of femur
different defect area
peripheral cartilage
stress
three-dimensional finite element analysis
