摘要
纤维化是一种病理过程,其以细胞外基质(extracellular matrix,ECM)的大量沉积为主要特征。纤维化发生在包括肺、肝脏、心脏和肾脏在内的各种器官中,最终导致器官结构扭曲和严重功能障碍。1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)是一种具有生物活性的溶血磷脂,发挥多种活性,包括细胞增殖、存活、分化、迁移、炎症、血管生成和内皮屏障完整性等过程。越来越多的证据表明,SphK1/S1P信号通路在肺纤维化疾病的发生发展中起着重要作用,研究其相关作用与功能,可为治疗难治性纤维化性疾病提供新的思路和药物治疗靶点。
Fibrosis is a pathological process characterized by massive deposition of extracellular matrix(ECM).Fibrosis occurs in various organs including the lung,liver,heart,and kidney,eventually leading to structural distortion and severe dysfunction.Sphingosine-1-phosphate(S1P)is a biologically active lysophospholipid that exerts a variety of activities including cell proliferation,survival,differentiation,migration,inflammation,angiogenesis,and endothelial barrier integrity.Many studies suggests that SphK1/S1P signaling pathway plays an important role in the occurrence and development of pulmonary fibrosis.The functional mechanisms of S1P would provide potential therapeutic strategies and targets for refractory fibrotic diseases.
作者
刘利娟
李傲
LIU Lijuan;LI Ao(School of Pharmacy&Bioengineering,Chongqing University of Technology,Chongqing 400054,China)
出处
《济宁医学院学报》
2019年第6期424-427,共4页
Journal of Jining Medical University
基金
国家自然科学基金(81703687)
重庆市卫生和计划生育委员会中医药科技项目(ZY201702122)
重庆理工大学研究生创新项目(ycx2018250)
关键词
1-磷酸鞘氨醇
1-磷酸鞘氨醇受体
鞘氨醇激酶
肺纤维化
Sphingosine 1-phosphate
Sphingosine 1-phosphate receptors
Sphingosine kinases
Pulmonary fibrosis
