摘要
目的:探究早发型重度子痫前期(SPE)患者胎盘生长因子(PIGF)表达及与妊娠结局关系。方法:选取2017年1月-2018年12月本院收治的80例早发型SPE患者(观察组)及100例正常孕妇(对照组),检测两组分娩当日血浆PIGF水平并观察临床相关指标,依据PIGF水平分为PIGF异常组和正常组,分析早发型SPE孕妇PIGF水平及与妊娠结局关系。结果:观察组血浆PIGF水平低于对照组,SBP、DBP、S/D高于对照组(均P<0.05);早发型SPE孕妇中PIGF异常率为51.3%,PIGF异常组新生儿出生孕周、出生体重、胎盘重量、1 min Apgar评分均低于PIGF正常组,LAC、S/D高于PIGF正常组(P<0.05)。相关性分析发现,早发型SPE孕妇PIGF表达水平与SBP、DBP、脐动脉S/D呈负相关,与新生儿出生体重、1 min Apgar评分呈正相关(均P<0.05)。结论:早发型SPE孕妇PIGF表达水平与妊娠结局关系密切,PIGF对预测妊娠结局有一定临床价值,需加强关注。
Objective:To explore the expression of placental growth factor(PIGF)of pregnant women with early-onset severe preeclampsia(SPE),and to study its relationship with pregnancy outcomes.Methods:80 pregnant women with early-onset SPE were enrolled in observation group and 100 normal pregnant women were in control group from January 2017 to December 2018.On the delivery day,the plasma PIGF level of women in both groups was detected,and clinically relevant indexes of women in both groups were observed.The relationship between PIGF level of women in observation group and their pregnancy outcomes was analyzed.Results:The plasma PIGF level of women in the observation group were significant lower than that of women in the control group,but the values of SBP,DBP and S/D of women in the observation group were significant higher(P<0.05).The abnormal rate of plasma PIGF level of women in the observation group was 51.3%.The neonatal gestational weeks of birth,birth weight,placental weight,and 1 min Apgar score of pregnant women with abnormal PIGF level were significant lower than those of pregnant women with normal PIGF level(P<0.05),while values of LAC and umbilical artery S/D of pregnant women with abnormal PIGF level were significant higher(P<0.05).Correlation analysis showed that the expression level of PIGF of pregnant women with early-onset SPE were negatively correlated with the values of SBP,DBP and umbilical artery S/D,while were positively correlated with neonatal birth weight and 1 min Apgar score(P<0.05).Conclusion:The expression level of PIGF of pregnant woman with early-onset SPE is closely related to pregnancy outcomes.The PIGF level of pregnant women has some clinical value for predicting pregnancy outcomes,so it should be more focused on.
作者
王慧娟
唐淑稳
兰淑海
WANG Huijuan;TANG Shuwen;LAN Shuhai(Baodi District People's Hospital,Tianjin,301800)
出处
《中国计划生育学杂志》
2019年第12期1693-1696,共4页
Chinese Journal of Family Planning
关键词
早发型
重度子痫前期
胎盘生长因子
妊娠结局
Early-onset
Severe preeclampsia
Placental growth factor
Pregnancy outcomes
