摘要
目的 探讨注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白联合玻璃酸钠关节腔注射治疗类风湿关节炎的临床疗效.方法 选择大同市第二人民医院2016年2月至2018年2月治疗的类风湿关节炎患者40例为观察对象,采用随机数字表法分为观察组和对照组各20例,观察组采用注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白联合玻璃酸钠关节腔注射治疗,对照组采用单纯注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白关节腔注射治疗.比较两组治疗前后关节肿胀、关节疼痛、关节活动度、晨僵、X线表现评分及总有效率.结果 治疗前,两组关节疼痛、关节压痛、关节活动度、晨僵、临床评分和X线分期等差异均无统计学意义(均P>0.05).治疗后,两组患者症状和体征明显好转,观察组关节疼痛、关节压痛、关节活动度、晨僵及总评分分别为(1.2 ± 1.2)分、(0.8 ± 0.7)分、(0.5 ± 0.4)分、(0.7 ± 0.7)分、(4.5 ± 2.6)分,均明显优于对照组的(2.2 ± 1.4)分、(1.5 ± 0.9)分、(1.5 ± 0.9)分、(1.5 ± 0.6)分、(8.6 ± 4.6)分(U=125、111、68、89、97,均P<0.05).观察组总有效率为100%(20/20),对照组总有效率为75%(15/20),两组差异有统计学意义(χ^2 =14.10,P<0.01).结论 注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白联合玻璃酸钠关节腔注射治疗类风湿关节炎可有效改善患者的临床症状,而且较单用效果明显.
Objective To investigate the clinical efficacy of recombinant human tumor necrosis factor-α receptor II:IgG Fc fusion protein combined with sodium hyaluronate in the treatment of rheumatoid arthritis(RA).Methods Forty adult RA patients(12 males,28 females)aged from 36 to 79 were selected in Department of Rheu-matology of the Second People's hospital of Datong from February 2016 to February 2018.The patients were randomly divided into the observation group and the control group according to the digital table,with 20 cases in each group.The observation group was treated by intra-articular injection of recombinant human tumor necrosis factor-α receptor II:IgG Fc fusion protein and sodium hyaluronate,and the control group was only treated with recombinant human tumor necrosis factor-α receptor II:IgG Fc fusion protein.The joint swelling,joint pain,joint mobility,morning stiffness,X-ray grade and total effective rate of the two groups were statistically analyzed before and after treatment.Results Before treatment,there were no statistically significant differences in joint swelling,joint pain,joint mobility,morning stiffness,clinical score and X-ray grade between the two groups(all P>0.05).After treatment,the symptoms and signs of the two groups were obviously improved.The joint pain,joint pressure pain,joint activity,morning stiffness and clinical score in the observation group were(1.2 ± 1.2)points,(0.8 ± 0.7)points,(0.5 ± 0.4)points,(0.7 ± 0.7)points and(4.5 ± 2.6)points,respetively,which were significantly better than those in the control group [(2.2 ± 1.4)points,(1.5 ± 0.9)points,(1.5 ± 0.9)points,(1.5 ± 0.6)points and(8.6 ± 4.6)points,U=125,111,68,89 and 97,all P<0.05].The total effective rate of the observation group was 100%(20/20),while that of the control group was 75%(15/20),there was statistically significant difference between the two groups(χ^2 = 14.10,P<0.01).Conclusion The injection of recombinant human tumor necrosis factor-α receptor II:IgG Fc fusion protein combined with sodium hyalur
作者
孙笑丛
马红玲
赵娟
李亚琦
徐志鹏
王晓英
陈敏
Sun Xiaocong;Ma Hongling;Zhao Juan;Li Yaqi;Xu Zhipeng;Wang Xiaoying;Chen Min(Department of Rheumatology,the Second People′s Hospital of Datong,Datong,Shanxi 037000,China Ma Hongling)
出处
《中国基层医药》
CAS
2019年第23期2822-2825,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
山西省大同市科技攻关项目(2016077)。
关键词
关节炎
类风湿
肿瘤坏死因子受体相关肽和相关蛋白质类
玻璃酸钠
注射
关节内
随机对照试验
Arthritis,rheumatoid
Tumor necrosis factor receptor-associated peptides and proteins
Hyaluronic acid
Injections,intra-articular
Randomized controlled trial
