摘要
目的 分析类风湿关节炎疾病应用雷公藤多甙与免疫抑制剂联合治疗的有效价值。方法 选取2021年5月—2023年1月内蒙古科技大学包头医学院第一附属医院风湿免疫科类风湿关节炎患者70例,以随机数字表法分为免疫干预组(免疫抑制剂治疗)与联合干预组(免疫抑制剂联合雷公藤多甙),各35例。评估两组患者的症状积分情况、炎症因子的变化、总有效率、不良反应以及免疫功能指标变化。结果 干预后,联合干预组关节肿胀为(0.49±0.52)分、关节疼痛为(0.34±0.05)分、晨僵为(0.43±0.02)分,均优于免疫干预组的(0.91±0.25)分、(0.83±0.41)分、(0.91±0.16)分(P <0.05)。联合干预组有效率高于免疫干预组(P <0.05)。联合干预组患者红细胞沉降率、C-反应蛋白指标、类风湿因子指标均小于免疫干预组(P <0.05),即联合干预组炎症因子指标变化程度更大。联合干预组有2例患者出现腹部疼痛、1例患者出现胃肠道不舒适、2例患者出现恶心呕吐,发生率为14.3%,低于免疫干预组的28.6%(P <0.05)。结论 类风湿关节炎的治疗中,应首选雷公藤多甙联合免疫抑制剂治疗方法,能更好地减少症状积分,调整炎症因子指标,保障治疗效率。
Objective To analyze the effective value of polyside and immunosuppressive agent in rheumatoid arthritis.Methods From May 2021 to January 2023,a total of 70 patients with rheumatoid arthritis in the Department of the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology were divided into immune intervention group(immunosuppressive agent therapy)and combined intervention group(immunosuppressant agent and polyside),respectively,by random number method.Symptoms and integration,changes in inflammatory factors,total response rate,and adverse effects were assessed in both groups.Results After intervention,the joint swelling score,joint pain score,and morning stiffness score of the combined intervention group were(0.49±0.52)points,(0.34±0.05)points,and(0.43±0.02)points,all of which were better than the immune intervention group's(0.91±0.25)points,(0.83±0.41)points,and(0.91±0.16)points(P<0.05).The effective rate of the combined intervention group was higher than that of the immune intervention group(P<0.05).The red blood cell sedimentation rate,C-reactive protein index,and rheumatoid factor index of patients in the combined intervention group were all lower than those in the immune intervention group,indicating a greater degree of changes in inflammatory factor indicators in the combined intervention group(P<0.05).Two patients in the combined intervention group experienced abdominal pain,one patient experienced gastrointestinal discomfort,and two patients experienced nausea and vomiting,with an incidence rate of 14.3%,lower than the 28.6%in the immune intervention group(P<0.05).Conclusion In the treatment of rheumatoid arthritis,the treatment method of combined with immunosuppressive agent should be preferred to better reduce the symptom integral,adjust the inflammatory factors,and ensure the treatment efficiency,which can be promoted.
作者
马瑞雪
孙英梅
MA Ruixue;SUN Yingmei(Department of Rheumatology and Immunology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou Inner Mongolia 014010,China;Department of Endocrinology,Wuhai People's Hospital,Wuhai Inner Mongolia 016000,China)
出处
《中国卫生标准管理》
2023年第21期141-144,共4页
China Health Standard Management
