摘要
秀丽隐杆线虫是一种结构简单且与人类基因在功能上具有高度保守性的模式生物,因其特点鲜明,所以广泛应用于人类疾病研究中,并在2型糖尿病研究中备受关注。目前,2型糖尿病发病机制尚未完全明确,现有的治疗手段会对人体带来许多副作用。利用秀丽隐杆线虫建立2型糖尿病研究模型,与其他2型糖尿病细胞模型和动物模型相比会带来不同的研究策略。本文综述了近年国内外秀丽隐杆线虫模型在2型糖尿病中相关研究进展,为后续研究提供理论参考。
Caenorhabditis elegans is a model organism with simple structure and highly conserved with human genes in function.It is widely used in the human disease research,especially for type 2 diabetes mellitus(T2 DM)due to its distinctive characteristics.At present,the pathogenesis of T2 DM remains unclear,and many side effects of drug treatments would threaten the human bodies.Compared with other cells and animals,diabetes mellitus model in C.elegans would bring the different research strategies.The paper summarizes the research progress of diabetes mellitus model in C.elegans for recent years,which can provide the theoretical basis for further study.
作者
刘思迪
钟汝婷
刘丹
杨成凤
刘媛媛
赵超
LIU Sidi;ZHONG Ruting;LIU Dan;YANG Chengfeng;LIU Yuanyuan;ZHAO Chao(College of Life Science,Yantai University,Yantai,Shandong 264005,China)
出处
《中国微生态学杂志》
CAS
CSCD
2019年第11期1347-1350,1355,共5页
Chinese Journal of Microecology
基金
国家自然科学基金(81741163)
福建省杰出青年科学基金(2016J06009)
福州市科技计划(2018-G-87)
关键词
秀丽隐杆线虫
2型糖尿病
血糖
血脂
Caenorhabditis elegans
Type 2 diabetes mellitus
Blood sugar
Blood lipids
