摘要
研究表明含有螺环氧化吲哚骨架的化合物具有多种药理活性,如抗癌、抗炎、抗菌、抗病毒、抗疟疾和抑制胆碱酯酶等,其中抗肿瘤活性在此类骨架结构中尤为突出。根据螺环氧化吲哚骨架上2-吲哚酮C(3)位置上的螺杂环结构的不同进行分类,介绍近年来被报道具有抗肿瘤活性的标题化合物的研究进展,并对其作为可开发的抗肿瘤新药先导化合物的研究前景予以展望。
Spirooxindoles have a variety of superior pharmacological activities,such as anticancer,antiinflammatory,antibacterial,antivirus,antimalaria and anticholinesterase.The anticancer activity is the most prominent among the biological activities of such skeletons.According to the different structure of spiro heterocycles in the position of 2-indolinone C(3)on the spiro-indole skeleton,the research progress of title compounds with antitumor activity reported in recent years was reviewed.The prospect of the compounds is also discussed as lead compounds for anticancer drugs.
作者
王碧川
陈凯镔
朱宝磊
钟伟鹏
陈清
林宁
WANG Bi-chuan;CHEN Kai-bin;ZHU Bao-lei;ZHONG Wei-peng;CHEN Qing;LIN Ning(Guangxi Zhuang Yao Medicine Center of Engineering and Technology,School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530001,China)
出处
《化学试剂》
CAS
北大核心
2019年第12期1271-1281,共11页
Chemical Reagents
基金
国家自然科学基金资助项目(21861009)
广西自然科学基金资助项目(2018GXNSFAA281317,2016GXNSFAA-380178)
广西中医药大学硕士研究生科研创新项目(YCSY2018050)
关键词
螺环氧化吲哚
研究进展
药理活性
抗肿瘤
作用机制
spirooxindole
research progress
pharmacological activities
anticancer
mechanisms of action
