摘要
手性3-氨基-2-吲哚酮骨架广泛存在于许多药物分子以及天然产物中,具有较高的药用价值。靛红亚胺参与的不对称反应是合成手性3-氨基-2-吲哚酮衍生物的直接途径。本文围绕着不对称aza-Henry反应、不对称环化反应及其他不对称反应3个方面,综述了靛红亚胺参与构建手性3-氨基-2-吲哚酮衍生物的研究进展并进行了展望。
The chiral 3 amino 2 oxindole skeletons are widely present in many drug molecules and natural products and show high medicinal value. The asymmetric reaction involving of isatin derived ketimines provides a direct access to chiral 3 amino 2 oxindole derivatives. In this paper the recent progress on the asymmetric aza Henry cyclization and other asymmetric reactions for the construction of 3 amino 2 oxindoles skeleton with isatin derived ketimines is reviewed and the future development is prospected.
作者
张俊伟
吴昊
陈哲
金瑛
姜英子
ZHANG Junwei;WU Hao;CHEN Zhe;JIN Ying;JIANG Yingzi(Department of Pharmacy,Yanbian University,Yanji,Jilin 130000,China;Department of Pharmacy,Jilin Medical University,Jilin,Jilin 132013,China)
出处
《应用化学》
CAS
CSCD
北大核心
2019年第12期1343-1360,共18页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金(21102055)
吉林省教育厅“十三五”科学技术项目(JJKH20180835KJ)
吉林省卫生厅创新项目(2017J104)资助~~
