摘要
[目的]研究腹腔内灌注化疗(HIPEC)联合卡培他滨+奥沙利铂(XELOX)治疗晚期胃癌患者的效果及对血清食欲素(Orexin A)、血管内皮细胞生长因子(VEGF)水平的影响。[方法]选取我院于2015年10月~2017年5月收治的180例晚期胃癌患者,依据随机数字表法分为观察组和对照组,每组90例。对照组采用XELOX化疗,观察组在对照组基础上联合使用顺铂腹腔内灌注化疗。比较2组患者的近期疗效,以及热化疗期间营养指标、生活质量、血清Orexin A和VEGF水平差异,并统计2组不良反应发生情况。[结果]观察组近期有效率(75.56%)显著高于对照组(57.78%),且经治疗后2组患者的KPS评分均显著降低,观察组KPS评分、住院费用显著高于对照组,住院时间显著优于对照组,差异有统计学意义(P<0.05)。2组患者经治疗后血清各营养指标(血清白蛋白、血清总蛋白、血清转铁蛋白)、血清Orexin A和VEGF水平均显著降低,且观察组各指标水平降低更显著,差异有统计学意义(P<0.05)。不良反应主要为骨髓抑制、胃肠道反应,2组患者的不良反应发生率差异无统计学意义。[结论]腹腔内灌注化疗联合XELOX治疗晚期胃癌的效果显著,可有效降低血清Orexin A、VEGF水平,改善预后,值得临床推广。
[Objective]To study the effect of intraperitoneal infusion chemotherapy(HIEPC)combined with oxaliplatin(XELOX)in the treatment of patients with advanced gastric cancer and its effect on serum level of Orexin A and vascular endothelial growth factor(VEGF).[Methods]180 patients with advanced gastric cancer treated in our hospital from October 2015 to May 2017 and were divided into observation group and control group according to random digital table,90 cases per group.The control group was treated with XELOX,while the patients in the observation group were treated with intraperitoneal infusion chemotherapy combined with XELOX.The short-term curative effect,nutritional index,quality of life,serum Orexin A and VEGF levels were compared between the two groups,and the adverse reaction events were analyzed.[Results]The short-term effective rate of observation group(75.56%)was significantly higher than that of control group(57.78%),and the KPS score in the two groups were significantly decreased after treatment.The KPS scores and hospitalization costs in the observation group were significantly higher than that in the control group and the hospitalization time was significantly better than those in the control group,with statistical significance(P<0.05).The levels of serum Alb,TPN,TFR,Orexin A and VEGF in the two groups were significantly decreased after treatment,but the levels of serum indexes in the observation group were significantly lower than that in the control group,with statistical significance(P<0.05).The main adverse reactions were myelosuppression and gastrointestinal reactions,and there were no significant difference in the incidence of adverse reactions between the two groups(P>0.05).[Conclusion]Intraperitoneal infusion chemotherapy combined with XELOX is effective on advanced gastric cancer.It can effectively reduce the level of serum Orexin A and VEGF,improve the prognosis and be worth popularizing in clinically.
作者
李磊
李向利
LI Lei;LI Xiang-li(Department of General Surgery,Xiangchcng People’s Hospital,Suzhou 215131,China)
出处
《中国中西医结合消化杂志》
CAS
2019年第12期934-938,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
灌注化疗
肠胃肿瘤
XELOX
食欲素
血管内皮细胞生长因子
intraperitoneal infusion chemotherapy
gastrointestinal cancer
oxaliplatin
Orexin A
vascular endothelial growth factor
