摘要
目的探究在B组链球菌(GBS)感染所致新生儿化脓性脑膜炎中联合使用头孢曲松钠与氨苄西林治疗的临床效果。方法选取2016年5月至2018年5月在本院确诊为由GBS感染而致化脓性脑膜炎的患儿80例为研究对象,随机分为对照组和联合组,各40例。对照组在进行常规治疗的基础上给予氨苄西林治疗,联合组在对照组的基础上使用头孢曲松钠进行治疗。通过比对患儿脑脊液恢复正常时间、颅高压消失时间等体征指标,脑脊液的生化指标以及并发症的发生情况分析临床效果。结果对照组的临床体征(颅高压、体温、脑脊液)恢复时间均比联合组恢复时间长,差异具有统计学意义(P<0.05);联合组脑脊液的生化指标明显优于对照组,差异具有统计学意义(P<0.05);联合组并发症的发生率(2.50%)低于对照组(22.50%),差异具有统计学意义(P<0.05)。结论头孢曲松钠联合氨苄西林治疗GBS感染所致新生儿化脓性脑膜炎的临床效果优良,值得临床推广应用。
Objective To explore the clinical effect of ceftriaxone sodium combined with ampicillin in the treatment of neonatal suppurative meningitis caused by streptococcal(GBS)infection in group B.Methods 80 children diagnosed in our hospital from May 2016 to May 2018 as purulent meningitis caused by GBS infection were selected as study objects,and randomly divided into control group and combination group,with 40 cases each.The control group received ampicillin in addition to conventional treatment,while the combination group received ceftriaxone sodium in addition to the control group.The clinical effect was analyzed by comparing the cerebrospinal fluid recovery time,cranial pressure disappearance time and other signs,biochemical indexes of cerebrospinal fluid and the occurrence of complications.Results The recovery time of clinical signs(cranial hypertension,body temperature,cerebrospinal fluid)in the control group was longer than that in the combined group,and the difference was statistically significant(P<0.05).The biochemical indexes of CSF in the combined group were significantly better than those in the control group,and the difference was statistically significant(P<0.05).The incidence of complications in the combination group(2.50%)was lower than that in the control group(25.00%),and the difference was statistically significant(P<0.05).Conclusion Ceftriaxone sodium combined with ampicillin in the treatment of neonatal suppurative meningitis caused by GBS infection has a good clinical effect and is worthy of clinical application.
作者
黄乐明
Huang Leming(Department of Pediatrics,Ganzhou People's Hospital,Ganzhou,Jiangxi,341000,China)
出处
《当代医学》
2019年第36期30-32,共3页
Contemporary Medicine
