摘要
目的探讨四氢叶酸还原酶基因多肽性与妊娠高血压患者母婴结局的关系。方法收集本院2017年8月-2018年8月住院患者90例妊娠高血压合并妊娠结局不良的患者作为研究对象,所有患者均检测MTHFR基因多态性,对比各组基因多态性的分布与产妇并发症和妊娠并发症的关系,以及各基因型患者血清中Hcy水平。结果基因型为A/A的患者血清中Hcy水平明显高于基因型为A/C和C/C的患者(P<0.05),基因型为A/A的产妇胎盘早剥、DIC、急性肾功能衰竭、HEPPLP综合征、左心功能衰竭的发病率均明显高于基因型为A/C和C/C的产妇(P<0.05),基因型为A/A的产妇在新生儿窒息、胎儿宫内窘迫、围生期死亡、剖宫产中的发病率明显高于基因型为A/C和C/C的产妇(P<0.05)。结论四氢叶酸还原酶基因多肽性与妊娠高血压患者不良结局密切相关。
Objective To investigate the relationship between polypeptide of tetrahydrofolate reductase gene and maternal and infant outcomes in patients with pregnancy induced hypertension. Methods A total of 90 patients with pregnancy-induced hypertension complicated with poor pregnancy outcome were collected from September 2017 to September 2018. MTHFR gene polymorphisms were detected in all patients. The relationship between the distribution of MTHFR gene polymorphisms, maternal complications and pregnancy complications, and the serum Hcy level in patients with different genotypes were compared. Results The serum level of Hcy in patients with genotype A/A was significantly higher than that in patients with genotype A/C and C/C(P<0.05). The incidence of placental abruption, DIC, acute renal failure, HEPPLP syndrome and left ventricular failure in patients with genotype A/A was significantly higher than that in patients with genotype A/C and C/C(P<0.05). The incidence of neonatal asphyxia, fetal distress, perinatal death and cesarean section was significantly higher in women with genotype A/A than genotype A/C and C/C(P<0.05). Conclusion The polypeptide of the folate reductase gene is closely related to the adverse outcome of hypertensive disorder complicating pregnancy.
作者
金海红
刘惠宁
JIN Hai-hong;LIU Hui-ning(Taizhou Hospital,Linhai,Zhejiang 317000,China;不详)
出处
《中国卫生检验杂志》
CAS
2019年第23期2885-2886,2890,共3页
Chinese Journal of Health Laboratory Technology
关键词
妊娠
叶酸基因多态性
妊娠高血压
预后
Pregnancy
Folate gene polymorphism
Pregnancy induced hypertension
Prognosis
