摘要
目的:探讨盐酸氨溴索联合沙丁胺醇与布地奈德治疗慢性阻塞性肺疾病(COPD)的临床效果。方法:选取收治的60例COPD患者为研究对象,按照随机数字表法分为对照组和观察组,每组30例。对照组予沙丁胺醇联合布地奈德治疗,观察组在对照组基础上予盐酸氨溴索治疗,比较两组治疗前后肺功能、症状评分,呼吸困难、咳嗽、咳痰缓解时间及住院时间,以及不良反应发生率。结果:观察组呼吸困难、咳嗽、咳痰缓解时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,观察组FEV1、FVC、PEF水平均高于对照组,痰量、气促、咳嗽临床症状评分均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸氨溴索联合沙丁胺醇与布地奈德治疗慢性阻塞性肺疾病效果较好,可改善患者肺功能,缓解临床症状,值得推荐。
Objective:To investigate clinical effects of Ambroxol hydrochloride combined with Salbutamol and Budesonide in treatment of chronic obstructive pulmonary disease(COPD).Methods:Sixty patients with COPD were enrolled in the study.They were divided into control group and observation group according to the random number table method,30 cases in each group.The control group was treated with Salbutamol and Budesonide,while the observation group was treated with Ambroxol hydrochloride on the basis of those of the control group.The pulmonary function before and after the treatment,symptom score,dyspnea,cough,cough relief time and hospitalization time,and incidence of adverse reactions were compared between the two groups.Results:The dyspnea,cough,cough relief time and hospitalization time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the FEV1,FVC and PEF levels in the observation group were higher than those in the control group,the clinical symptom scores of sputum volume,shortness of breath and cough were lower than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ambroxol hydrochloride combined with Salbutamol and Budesonide have significant effects in the treatment of chronic obstructive pulmonary disease,and can improve the pulmonary function of the patients and relieve the clinical symptoms,which is recommended.
作者
马得英
MA Deying(Department of Respiratory Medicine of Feng County Hospital of Traditional Chinese Medicine,Xuzhou 221700 Jiangsu,China)
出处
《中国民康医学》
2019年第20期14-16,共3页
Medical Journal of Chinese People’s Health
关键词
盐酸氨溴索
沙丁胺醇
布地奈德
慢性阻塞性肺疾病
肺功能
Ambroxol hydrochloride
Salbutamol
Budesonide
Chronic obstructive pulmonary disease
Pulmonary function
