摘要
目的探讨丹参多酚酸盐对冠状动脉粥样硬化性心脏病(简称冠心病)患者内皮功能及氧化应激状态的影响。方法选取医院2016年12月至2018年12月收治的冠心病患者80例,按随机数字表法分为对照组和研究组,各40例。两组患者均予抗凝、调血脂、扩血管等常规治疗,研究组患者加用注射用丹参多酚酸盐静脉滴注。结果与治疗前比较,两组患者治疗后的血管假性血友病因子(vWF)、内皮素-1(ET-1)、丙二醛(MDA)水平均显著降低,一氧化氮(NO)、超氧化物歧化酶(SOD)水平均显著升高,且研究组患者上述指标改善程度显著优于对照组(P<0.05);研究组不良反应发生率为10.00%,显著低于对照组的17.50%(P<0.05)。结论常规治疗联合丹参多酚酸盐治疗冠心病有一定疗效,可改善血管内皮功能和氧化应激状态。
Objective To investigate the effect of salvianolate on endothelial function and oxidative stress in patients with coronary heart disease(CHD).Methods Totally 80 patients with CHD admitted to our hospital from December 2016 to December 2018 were selected and divided into the control group and the study group according to the random number table method,40 cases in each group.The patients in the two groups were given conventional therapy such as anticoagulation,regulation of blood lipid,vasodilation and so on.On this basis,the patients in the study group were given intravenous infusion of Salvianolate for Injection.Results Compared with those before treatment,the levels of von Willebrand factor(vWF),endothelin-1(ET-1)and malondialdehyde(MDA)were significantly decreased,while the levels of nitric oxide(NO)and superoxide dismutase(SOD)were significantly increased in the two groups,and the improvement of the above indexes in the study group was significantly better than that in the control group(P<0.05).The incidence of adverse reactions in the study group was 10.00%,which was significantly lower than 17.50%in the control group(P<0.05).Conclusion Conventional therapy combined with salvianolate has a certain effect in the treatment of patients with CHD,which can improve endothelial function and oxidative stress.
作者
关敬树
周云
缪志静
高山钟
陈佳
GUAN Jingshu;ZHOU Yun;MIAO Zhijing;GAO Shanzhong;CHEN Jia(Department of Cardiology,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai,China 201999)
出处
《中国药业》
CAS
2019年第24期75-77,共3页
China Pharmaceuticals
关键词
冠心病
心绞痛
丹参多酚酸盐
内皮功能
氧化应激
coronary heart disease
angina pectoris
salvianolate
endothelial function
oxidative stress
