摘要
骨关节炎(OA)是以软骨退变及关节间隙变窄为主要特征,普遍存在且具有致残性的关节紊乱.目前对OA治疗的研究已不再局限于关节软骨,软骨下骨不论是结构还是生物学功能都在OA的发生发展过程中起重要作用.本文简要回顾软骨下骨和软骨在结构与功能上的联系以及软骨下骨在OA中的病理改变,着重对基于软骨下骨治疗骨关节炎的研究进展做一综述,并对近二十五年全球范围内软骨下骨的研究进行可视化分析.
Osteoarthritis(OA)is a common and disabling joint disorder,which is mainly characterized by cartilage degeneration and narrow joint space.Nowadays,the research on the therapy of OA is no longer limited to articular cartilage.Subchondral bone plays an important role in the genesis and development of OA,both in structure and biological function.This article briefly reviews the structural and functional association of subchondral bone and cartilage and the pathological change of subchondral bone in OA.The progress in the treatment of osteoarthritis based on subchondral bone was emphatically reviewed,and a global visualized analysis of subchondral bone in recent twenty five years was shared.
作者
毛兴佳
向川
Mao Xingjia;Xiang Chuan(Department of Orthopedics,the Second Affiliated Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2019年第12期2317-2322,共6页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金(81972075、81472091)
山西省国际合作项目(201803D421050)
山西省高等学校大学生创新创业训练基金(2018161)。
关键词
软骨下骨
骨关节炎
治疗
可视化分析
Subchondral bone
Osteoarthritis
Therapy
Visualized analysis
