摘要
目的探讨肝婴儿型肝血管内皮瘤(IHH)的临床病理特征、免疫表型、诊断及鉴别诊断。方法回顾性分析7例IHH的临床特征、形态学特点、免疫表型,并复习相关文献。结果7例IHH患儿,年龄8~13月,平均年龄4.1月,男性2例,女性5例,4例位于肝右叶,3例位于肝左叶。大体1例肉眼可见完整包膜,6例与周围肝组织分界不清,质地软至中等,切面灰白、暗红交替,部分有出血。镜下肿瘤由大量血管构成,管腔大小不一,形态不规则,大部分区域为毛细血管构成,部分肿瘤内可见陷入的小胆管。免疫组化:肿瘤细胞表达CD31、CD34及ERG。结论IHH是一种好发于婴儿的肝脏良性肿瘤,具有独特的组织学特征,需与多种疾病鉴别,对IHH的诊断及鉴别诊断有重要的临床意义。
Objective To investigate the clinicopathologic and immunohistochemistry features,diagnosis and differential diagnosis of infantile hepatic hemangioma(IHH).Methods A total of 7 cases of IHH were collected and the clinical,morphological,and immunohistochemical features were carefully analyzed.The previous reports on IHH were also reviewed.Results The patients were 5 females and 2 males with a mean age of 4.1 months(range:8 to 13 months).Four cases were located in the right lobe,3 cases located in the left lobe.On gross exa mination,1 case was encapsulated,and 6 cases did not have a clear boundary.The texture of the tumor was soft to medium with a gray white to dark red cut surface.Hemorrhage was seen in some areas.Histologically,the tumor was composed of a large number of irregular vessels with diverse size.Most vessels were capillaries.Trapped small bile duct was detected in some cases.Immunohistochemically,the tumor was positive for CD31,CD34 and ERG.Conclusion IHH is a benign tumor of infant liver,which has unique histological characteristics and needs to be differentiated from a variety of diseases.The correct diagnosis and differential diagnosis of IHH have significant clinical significance.
作者
胡美香
户燕姣
林东亮
信芳杰
宋腾腾
孙晓莉
潘广佳
HU Mei-xiang;HU Yan-jiao;LIN Dong-liang;XIN Fang-jie;SONG Teng-teng;SUN Xiao-li;PAN Guang-jia(Departmant of Pathology,Qixia People's Hospital,the affiliated Hospital of Qingdao University;不详)
出处
《诊断病理学杂志》
2019年第11期731-734,756,共5页
Chinese Journal of Diagnostic Pathology
关键词
肝肿瘤
婴儿肿瘤
血管瘤
免疫表型
Liver neoplasms
Infantile neoplasms
Hemangioma
Immunophenotype
