摘要
目的探讨甘精胰岛素联用阿卡波糖治疗老年糖尿病患者的临床效果及安全性。方法选择我院2016年1月~2019年1月收治的80例老年糖尿病患者作为研究对象,按照随机数字表法分为两组,每组40例,对照组给予甘精胰岛素,观察组给予甘精胰岛素+阿卡波糖,比较两组临床疗效、血糖水平、血糖达标时间、胰岛素用量、动态血糖监测指标。结果 (1)观察组临床总有效率95.00%,高于对照组80.00%(P<0.05)。(2)治疗后,观察组的空腹及餐后2 h血糖水平与对照组相比均更低(P<0.05)。(3)观察组血糖达标时间短于对照组,观察组胰岛素用量少于对照组(P<0.05)。(4)高血糖时间比、低血糖时间比、血糖波动系数在组间比较均无统计学差异(P>0.05),观察组低血糖发生率(5.00%)与对照组(2.50%)相比无统计学差异(P>0.05)。结论甘精胰岛素与阿卡波糖联合应用可提高老年糖尿病的临床疗效,可有效控制血糖水平,还不会增加低血糖风险,安全性良好。
Objective To investigate the clinical efficacy and safety of insulin glargine combined with acarbose in the treatment of elderly patients with diabetes mellitus. Methods 80 elderly patients with diabetes mellitus admitted to our hospital from January 2016 to January 2019 were enrolled in the study. They were divided into two groups according to the random number table, with 40 patients in each group. The control group was given insulin glargine. And the observation group was treated with insulin glargine +acarbose. The clinical efficacy, blood glucose level, blood glucose compliance time, insulin dosage, dynamic blood glucose monitoring indicatorbetween two groups were compared. Results(1)The total clinical effective rate of the observation group was 95.00%, which was higher than 80.00% in the control group(P<0.05).(2)After treatment, the fasting and postprandial 2 h blood glucose levels of the observation group were lower than those of the control group(P<0.05).(3)The blood glucose compliance time of observation group was shorter than that of the control group, and the insulin dosage in the observation group was less than that of the control group(P<0.05).(4)There was no significant difference in the time ratio of hyperglycemia, the time ratioof hypoglycemia, and the fluctuation coefficient of blood glucose between the groups(P>0.05). There was no significant difference in the incidence of hypoglycemia between 5.00% in the observation group and2.50% in the control group(P>0.05). Conclusion The combination of insulin glargine and acarbose can improve the clinical efficacy of senile diabetes, effectively control blood sugar levels, and not increase the risk of hypoglycemia, with good safety.
作者
钟丽颖
孙叶海
王聪
项金华
李顺东
ZHONG Liying;SUN Yehai;WANG Cong;XIANG Jinhua;LI Shundong(Department of Geriatrics,the Third Hospital of Changsha,Changsha410015,China)
出处
《中国现代医生》
2019年第32期26-28,共3页
China Modern Doctor
关键词
糖尿病
阿卡波糖
甘精胰岛素
血糖
Diabetes mellitus
Acarbose
Insulin glargine
Blood glucose
