摘要
目的探讨分析阿卡波糖和胰岛素治疗老年2型糖尿病的效果和安全性。方法选取2019年1月~2020年6月于淄博市周村区疾病预防控制中心门诊部就诊的76例2型糖尿病患者作为研究对象。按照随机数字表分为常规组(38例)和联合组(38例)。常规组用药方案为胰岛素治疗,联合组用药方案在常规组基础上应用阿卡波糖治疗。比较两组治疗前后血糖、胰岛素功能及不良反应总发生率。结果两组治疗前的糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(2 h PG)比较,差异无统计学意义(P>0.05);联合组治疗后的HbA1c、FBG、2 h PG均低于常规组,差异有统计学意义(P<0.05);两组治疗前的胰岛B细胞功能指数(HOMA-B)以及胰岛素抵抗指数(HOMA-IR)比较,差异无统计学意义(P>0.05);联合组治疗后的HOMA-B水平高于常规组,HOMA-IR低于常规组,差异有统计学意义(P<0.05);联合组不良反应总发生率低于常规组,差异有统计学意义(P<0.05)。结论阿卡波糖联合胰岛素能够更好地对患者血糖水平进行调控,能够有效改善患者胰岛素功能,且具有更高的用药安全性,值得广泛推广应用。
Objective To explore the efficacy and safety of Acarbose and Insulin in the treatment of elderly type 2 diabetes.Methods A total of 76 patients with type 2 diabetes who visited the Department of Outpatient in Zibo Zhoucun District Center for Disease Control and Prevention from January 2019 to June 2020 were selected as the research subjects.According to the random number table method,they were divided into conventional group(38 cases)and combined group(38 cases).The conventional group was treated with Insulin,and the combined group was treated with Acarbose on the basis of the routine group.The blood glucose,insulin function and the total incidence of adverse reactions were compared between the two groups before and after treatment.Results There was no significant difference in glycated hemoglobin(HbA1c),fasting blood-glucose(FBG)and 2 h postprandial blood glucose(2 h PG)between the two groups before treatment(P>0.05).HbA1c,FBG,and 2 h PG in the combination group after treatment were lower than those in the conventional group,the differences were statistically significant(P<0.05).There were no significant differences in the islet B cell function index(HOMA-B)and insulin resistance index(HOMA-IR)between the two groups before treatment(P>0.05).HOMA-B level after treatment in the combination group was higher than that of the conventional group,and HOMA-IR was lower than that of the conventional group,the differences were statistically significant(P<0.05).The total incidence of adverse reaction in the combination group was lower than that in the conventional group,and the difference was statistically significant(P<0.05).Conclusion Acarbose combined with Insulin can better regulate the blood glucose level of patients,effectively improve the insulin function of patients,and has a higher drug safety,which is worthy of extensive promotion and application.
作者
王利平
WANG Li-ping(Department of Outpatient,Zibo Zhoucun District Center for Disease Control and Prevention,Shandong Province,Zibo255300,China)
出处
《中国当代医药》
CAS
2021年第11期76-78,共3页
China Modern Medicine
