摘要
目的对子宫内膜癌淋巴结转移的相关高危因素进行研究。方法对2005年1月至2014年12月内蒙古自治区人民医院妇科进行诊治的192例子宫内膜癌患者的临床病理资料进行回顾,分析淋巴结转移的高危因素。结果192例患者中位发病年龄54岁,Ⅰ期105例(54.7%),Ⅱ期46例(24.0%),Ⅲ期32例(16.7%),Ⅳ期9例(4.7%);20例(10.4%)有盆腔淋巴结转移,8例(11.8%)存在腹主动脉旁淋巴结的转移。单因素分析显示病理类型、术前CA125≥35 u/ml、组织学分级、肿瘤大小、深肌层浸润、宫旁受累、宫颈间质受累、腹腔冲洗液细胞学阳性等是淋巴结转移率的高危因素(P<0.05)。结论子宫内膜癌手术过程中应当充分考虑分化程度、病理类型、肌层浸润、CA125水平等高危因素,以决定是否进行淋巴切除,为患者制定个体化治疗方案提供依据。
Objective To study the high-risk factors of lymph node metastasis in endometrial cancer.Methods The clinical and pathological data of 192 patients with endometrial cancer diagnosed and treated in the Department of Gynecology,People's Hospital of Inner Mongolia Autonomous Region from January 2005 to December 2014 were reviewed.Results The median age of onset in 192 patients was 54 years,105 cases(54.7%)in stage Ⅰ,46 cases(24.0%)in stage Ⅱ,32 cases(16.7%)in stage Ⅲ,and 9 cases(4.7%)in stage Ⅳ;Twenty patients(10.4%)had pelvic lymph node metastasis,and8 patients(11.8%)had metastatic abdominal aortic lymph nodes.Univariate analysis showed that pathological type,preoperative CA125≥35 U/ml,histological grade,tumor size,deep myometrial invasion,parauterine involvement,cervical interstitial involvement,and peritoneal lavage fluid cytology were high risk for lymph node metastasis.Factors(P<0.05).Conclusion High risk factors such as degree of differentiation,pathological type,myometrial invasion,and CA125 level should be fully considered during surgery for endometrial cancer to determine whether to undergo lymphadenectomy and provide a basis for patients to develop individualized treatment plans.
作者
李雅洁
王轶琳
LI Ya-jie;WANG Yi-lin(Hohhot Maternal and Child Health Hospital,Hohhot 010010 China;People's Hospital of Inner Mongolia Autonomous Region,Hohhot 010017 China)
出处
《内蒙古医学杂志》
2019年第11期1281-1284,共4页
Inner Mongolia Medical Journal
基金
内蒙古自治区人民医院院内基金项目(编号:2016055)
关键词
子宫内膜癌
淋巴结
转移
endometrial cancer
lymph node
metastasis
