摘要
目的:分析应用复方阿嗪米特与盐酸伊托必利联合治疗慢性胰腺炎消化不良患者的效果与安全性。方法:择选笔者所在医院2015年1月-2019年5月治疗的52例慢性胰腺炎消化不良患者作为研究对象,按患者就诊奇偶顺序分为参考组与研究组,每组26例。参考组使用盐酸伊托必利治疗,研究组在参考组的基础上联用复方阿嗪米特治疗;对比两组治疗总有效率、发病频率、症状消失时间、住院时间、治疗前后各症状积分变化及用药不良反应情况。结果:研究组治疗总有效率(92.30%)高于参考组(69.23%),差异有统计学意义(P<0.05);研究组发病频率低于参考组,症状消失时间及住院时间均短于参考组,差异均有统计学意义(P<0.05);两组治疗后各项症状积分均低于治疗前,且研究组症状积分低于参考组,差异均有统计学意义(P<0.05);研究组用药不良发应发生率(15.38%)低于参考组(19.23%),但差异无统计学意义(P>0.05)。结论:复方阿嗪米特与盐酸伊托必利联合治疗慢性胰腺炎消化不良,可改善患者的临床症状,加快症状消失时间,减少其发病频率并缩短住院时间,两种药物联合治疗无明显药物毒副反应,其安全性较高。
Objective:To analyze the efficacy and safety of Compound Azintamide combined with Itopril Hydrochloride in treatment of chronic pancreatitis with dyspepsia.Method:Fifty-two patients with chronic pancreatitis and dyspepsia who were treated in our hospital from January 2015 to May 2019 were selected as the study subjects.They were divided into the reference group and the research group according to parity order of patients,26 cases in each group.The reference group was treated with Itopril Hydrochloride,the research group was treated with Compound Azintamide on the basis of the reference group.The treatment efficiency,incidence,disappearance time of symptoms,hospital stay,changes of symptom scores before and after treatment and adverse drug reactions were compared between the two groups.Result:The effective rate of treatment in the study group(92.30%)was higher than that in the reference group(69.23%),the difference was significant(P<0.05).The incidence of the disease in the study group was lower than that in the reference group,and the disappearance time and hospitalization time of the symptoms were shorter than those in the reference group,the differences were significant(P<0.05).After treatment,the scores of symptoms in both groups were lower than those before treatment,and the scores of symptoms in the study group were better than those in the reference group,the differences were significant(P<0.05).The incidence of adverse drug use stress in the study group(15.38%)was lower than that in the reference group(19.23%),but there was no significant difference(P>0.05).Conclusion:Compound Azintamide combined with Itopril Hydrochloride in the treatment of chronic pancreatitis dyspepsia can improve the clinical symptoms,speed up the disappearance of symptoms,reduce the incidence of symptoms and shorten hospitalization time.The combination of the two drugs has no obvious drug toxicity and side effects,and its safety is higher.
作者
陈建福
CHEN Jianfu(Zhangping City Hospital,Zhangping 364400,China)
出处
《中外医学研究》
2019年第32期14-16,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
