摘要
目的 观察替普瑞酮联合富马酸伏诺拉生治疗功能性消化不良的临床疗效。方法 选取2020年1月—2022年1月福建省泉州市农业学校医务室和泉州德诚医院门诊收治的功能性消化不良患者120例,按照入组顺序分为联合组和单药组,每组60例。单药组给予富马酸伏诺拉生治疗,联合组给予替普瑞酮联合富马酸伏诺拉生治疗,2组患者均治疗4周。比较2组患者临床疗效,治疗前后症状评分、胃肠激素水平及不良反应。结果 联合组患者总有效率为96.67%,高于单药组的81.67%(χ^(2)=6.988,P=0.008);治疗4周后,2组患者上腹部烧灼感、上腹疼痛、早饱及餐后饱胀症状评分均较治疗前降低,且联合组低于单药组(P<0.01);2组患者胃泌素(GAS)及胃动素(MTL)水平均较治疗前升高,且联合组高于单药组(P<0.01)。单药组与联合组患者不良反应总发生率比较差异无统计学意义(5.00%vs. 3.33%,χ^(2)=0.209,P=0.648)。结论 替普瑞酮联合富马酸伏诺拉生治疗功能性消化不良的效果较好,可有效改善患者症状,调节胃肠激素的分泌,且安全性较高。
Objective To observe the clinical efficacy of teprenone combined with voronosan fumarate in the treatment of functional dyspepsia. Methods A total of 120 patients with functional dyspepsia admitted to Quanzhou Agricultural School Clinic and Quanzhou Decheng Hospital Outpatients, Fujian Province from January 2020 to January 2022 were selected and divided into combined group and monotherapy group according to the order of inclusion, with 60 cases in each group. The monotherapy group was treated with vonoprazan fumarate, while the combined group was treated with teprenone combined with vonoprazan fumarate. Both groups were treated for 4 weeks. The therapeutic effects, symptom scores and gastrointestinal hormone levels of the patients before and after treatment were compared between the two groups, and the adverse reactions of the two groups were also compared. Results The total effective rate of the observation group was 96.67%, which was higher than 81.67% of the monotherapy group(χ^(2)=6.988, P=0.008). After 4 weeks of treatment, the symptoms scores of upper abdominal burning, upper abdominal pain, early satiety and postprandial fullness in the two groups were lower than those before treatment, and the observation group was lower than the monotherapy group(P<0.01). The levels of gastrin(GAS) and motilin(MTL) in the two groups were higher than those before treatment, and the observation group was higher than the monotherapy group(P<0.01). There was no significant difference in the total incidence of adverse reactions between the monotherapy group and the combined group(5.00% vs. 3.33%, χ^(2)=0.209, P=0.648). Conclusion Teprenone combined with vonoprazan fumarate has a good effect in the treatment of functional dyspepsia, which can effectively improve the symptoms of patients, regulate the secretion of gastrointestinal hormones, and has high safety.
作者
沈军虹
何志忠
SHEN Junhong;HE Zhizhong(Quanzhou Agricultural School,Fujian Province,,Quanzhou 362000,China;不详)
出处
《临床合理用药杂志》
2023年第2期13-16,共4页
Chinese Journal of Clinical Rational Drug Use
