摘要
目的:观察与探究伏立康唑对慢性阻塞性肺疾病(慢阻肺)合并肺部真菌感染患者肺顺应性及肺功能参数的影响。方法:选取82例慢阻肺合并肺部真菌感染患者为研究对象,将所有患者根据随机数字表法分为对照组41例和观察组41例。对照组采用氟康唑进行治疗,观察组采用伏立康唑进行治疗。统计与比较两组的临床总有效率、不良反应发生率、治疗前后不同时间的症状体征评分、肺顺应性及肺功能参数。结果:观察组的临床总有效率高于对照组,差异有统计学意义(P<0.05),治疗前两组患者的症状体征评分、肺顺应性及肺功能参数比较,差异无统计学意义(P>0.05),治疗后不同时间观察组的症状体征评分均低于对照组,肺顺应性及肺功能参数均好于对照组,差异有统计学意义(P<0.05),两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论:伏立康唑对慢阻肺合并肺部真菌感染患者肺顺应性及肺功能参数的影响较好,在本类患者中的应用价值较高。
Objective To observe and investigate the influence of voriconazole for pulmonary compliance and pulmonary function parameters of patients with chronic obstructive pulmonary disease complicated with pulmonary fungal infection.Method 82 patients with chronic obstructive pulmonary disease complicated with pulmonary fungal infection in our hospital from January 2016 to July 2017 were selected as the study object,and all the patients were divided into control group 41 cases and observation group 41 cases by the random number table.The control group were treated with fluconazol,the observation group were treated with voriconazole.Then the total effective rates,adverse reaction rates,symptom and sign scores,pulmonary compliance and pulmonary function parameters at different time before and after the treatment of two groups were analyzed and compared.Results The total effective rate of observation was higher than the rate of control group,the difference was statistically significant(P<0.05),the symptom and sign scores,pulmonary compliance and pulmonary function parameters of observation group before the treatment were compare,the difference was not statistically significant(P>0.05),the symptom and sign scores of observation group of observation group at different time after the treatment were all lower than those of control group,the pulmonary compliance and pulmonary function parameters were all better than those of control group,the differences were statistically significant(P<0.05),the adverse reaction rates of two groups had no obviously differences(P>0.05).Conclusion The influence of voriconazole for pulmonary compliance and pulmonary function parameters of patients with chronic obstructive pulmonary disease complicated with pulmonary fungal infection are better,and the application value in these patients are higher.
作者
冯银合
曾春芳
FENG Yin-he;ZENG Chun-fang(Department of respiratory medicine,The People′s Hospital of Deyang,Sichuan,Deyang 618000,China)
出处
《吉林医学》
CAS
2019年第12期2727-2729,共3页
Jilin Medical Journal
关键词
伏立康唑
慢阻肺
肺部真菌感染
肺顺应性
肺功能参数
Voriconazole
Chronic obstructive pulmonary disease
Pulmonary fungal infection
Pulmonary compliance
Pulmonary function parameters
