摘要
目的评价胞二磷胆碱注射液治疗急性脑梗死(ACI)昏迷的临床疗效,并观察其对血清不对称二甲基精氨酸(ADMA)、对氧磷酯酶1(PON-1)的影响。方法回顾性选取2017年5月至2019年5月榆林市第一医院神经内科收治的150例ACI昏迷患者,根据治疗方法将患者分为两组,每组各75例。两组患者均给予常规治疗,对照组患者给予替格瑞洛口服或鼻饲,90 mg/次,2次/d;观察组患者给予胞二磷胆碱注射液0.5 g+100 mg 5%葡萄糖注射液稀释后缓慢滴注;两组均坚持治疗14 d。观察两组患者的临床治疗效果,对比两组患者治疗前后的美国国立卫生研究院卒中量表(NIHSS)、格拉斯哥昏迷评分(GCS)以及血清不对称二甲基精氨酸(ADMA)、对氧磷酯酶1(PON-1)变化情况,统计两组患者治疗期间的药物不良反应发生情况。结果观察组患者的临床总有效率(89.33%)高于对照组(68.00%),差异具有统计学意义(P<0.05);两组患者治疗前后的NIHSS评分(9.20±0.69 vs.15.26±2.63分)、GCS评分(14.69±2.48 vs.11.23±2.32分)以及血清ADMA(29.68±4.22 vs.43.65±5.66分)和PON-1(178.63±15.26 vs.130.58±12.59分)差异均具有统计学意义(P<0.05);治疗后观察组患者的NIHSS评分、GCS评分以及血清ADMA和PON-1均优于对照组,差异具有统计学意义(P<0.05);两组患者在治疗期间均未见严重药物不良反应发生。结论胞二磷胆碱注射液治疗ACI昏迷的临床疗效良好,可以有效改善患者血清ADMA和PON-1,且用药安全性较好。
Objective To evaluate the clinical efficacy of citicoline injection in treatment of patients with acute cerebral infarction(ACI)coma,and to observe the effect of citicoline injection on serum levels of asymmetric dimethyl arginine(ADMA)and paraoxonase-1(PON-1).Methods By using retrospective study method,screening from May 2017 to May 2019 treated 150 patients with ACI coma in this experiment,using simple random grouping all of these patients can be divided into two groups,two groups of patients were given with conventional western medicine for treatment,patients in control group were given with Greg oral or nasal feeding,90 mg/times,2 times/d,patients in observation group were treated with cytidine diphosphate choline injection of 0.5 g pdiluted in 100 mg of 5%glucose for injection with slow drips,two groups of treatment adherence for 14 d.The clinical therapeutic effect of these two groups of patients,compared these two groups of patients before and after treatment in the United States National Institutes of Health Stroke Scale(NIHSS)scores,Glasgow Coma Scale(GCS)scores and ADMA,PON-1,statistics of two groups of patients during treatment of the occurrence of adverse drug reactions.Results The total clinical effective rate(89.33%)was higher in observation group than that in control group(68.00%),and the difference was statistically significant(P<0.05).The NIHSS scores before and after treatment in these two groups(9.20±0.69 vs.15.26±2.63)GCS scores(14.69±2.48 vs.11.23±2.32)and serum ADMA(29.68±4.22 vs.43.65±5.66)and PON-1(178.63±15.26 vs.130.58±12.59),and their difference was statistically significant(P<0.05).NIHSS scores,GCS scores and serum levels of ADMA and PON-1 were better in observation group than those in control group,and the difference was statistically significant(P<0.05).There was no serious adverse drug reaction observed in these two groups during the therapeutic course.Conclusion Citicoline injection has a good clinical effect in treatment of ACI coma,and it can effectively raise the serum l
作者
侯英娟
李婉宁
魏江
李亚娟
马亚玲
HOU Ying-juan;LI Wan-ning;WEI Jiang(Department of Neurology,Yulin First Hospital,Yulin Shaanxi 719000,China;Fuping County Hospital Clinical Pharmacy,Weinan Shaanxi 711700,China)
出处
《临床和实验医学杂志》
2019年第23期2527-2530,共4页
Journal of Clinical and Experimental Medicine
基金
陕西省科技攻关计划项目(编号:2014K11-03-01-05)
