摘要
目的对顺铂联合紫杉醇同步放化疗治疗非小细胞肺癌的临床效果进行分析和研究。方法选择该院在2015年7月—2018年4月期间收治的50例非小细胞肺癌患者作为研究对象,按照硬币法将其随机划分为两组,对照组25例,观察组25例。通过放疗的方式对对照组予以治疗,在对照组放疗的基础上,通过紫杉醇联合顺铂同步化疗的方式对观察组予以治疗。对两组患者的治疗效果予以分析和研究。结果对照组总有效率为68.0%,观察组总有效率为88.0%。观察组的总有效率明显高于对照组,两组患者相比,差异有统计学意义(χ^2=12.455,P<0.05)。对照组与观察组中Ⅲ、Ⅳ级粒细胞减少发生率为4.0%、16.0%,骨髓抑制率发生为8.0%、24.0%,恶心、呕吐发生率为24.0%、36.0%,放射性肺炎发生率为12.0%、20.0%。对照组的Ⅲ、Ⅳ级粒细胞减少、骨髓抑制、恶心、呕吐、放射性肺炎等不良反应的发生率均低于观察组。其中Ⅲ、Ⅳ级粒细胞减少、骨髓抑制发生率有,差异有统计学意义(χ^2=2.471、3.285,P<0.05),恶心、呕吐、放射性肺炎发生率,差异无统计学意义、(χ^2=0.173、0.455,P>0.05)。结论在非小细胞肺癌的临床治疗中应用顺铂联合紫杉醇同步放化疗具有很好的效果,能够使患者的生活质量得到有效改善,但是具有较多的不良反应。
Objective To analyze and study the clinical effect of cisplatin combined with paclitaxel in the treatment of non-small cell lung cancer. Methods A total of 50 patients with non-small cell lung cancer admitted to the hospital from July 2015 to April 2018 were enrolled in the study. They were randomly divided into two groups according to the coin method, 25 in the control group and 25 in the observation group. The control group was treated by radiotherapy.On the basis of radiotherapy in the control group, the observation group was treated by simultaneous chemotherapy with paclitaxel and cisplatin. The therapeutic effects of the two groups of patients were analyzed and studied. Results The total effective rate of the control group was 68.0%, and the total effective rate of the observation group was 88.0%. The total effective rate of the observation group was significantly higher than that of the control group, and the difference was significant between the two groups the difference was statistically significant(χ^2=12.455, P<0.05). The incidence of grade III and IV neutropenia in the control group and the observation group was 4.0% and 16.0%, the rate of bone marrow suppression was 8.0%, 24.0%, the incidence of nausea and vomiting was 24.0%, 36.0%, and the incidence of radiation pneumonitis was 12.0%, 20.0%. The incidence of adverse reactions such as stage III and IV neutropenia,myelosuppression, nausea, vomiting, and radiation pneumonitis in the control group were lower than those in the observation group. There were significant differences in the incidence of stage III and IV neutropenia and myelosuppression the difference was statistically significant(χ^2=2.471, 3.285, P<0.05). There was no significant difference in the incidence of nausea, vomiting and radiation pneumonitis the difference was not statistically significant(χ^2=0.173, 0.455, P>0.05).Conclusion The application of cisplatin combined with paclitaxel in the clinical treatment of non-small cell lung cancer has a good effect, which can effectively im
作者
刘哲
LIU Zhe(Department of Oncology,Yuncheng County People's Hospital,Yuncheng,Shandong Province,274700 China)
出处
《系统医学》
2019年第21期139-141,共3页
Systems Medicine
关键词
非小细胞肺癌
顺铂
紫杉醇
放化疗
效果
不良反应
Non-small cell lung cancer
Cisplatin
Paclitaxel
Radiotherapy
Effect
Adverse reactions
