摘要
目的探讨老年重症患者伏立康唑血药谷浓度(Cmin)监测的重要性。方法回顾性分析2014年1月~2018年12月安徽医科大学附属第三医院收治的老年危重症患者43例,所有患者使用伏立康唑治疗,监测并观察伏立康唑Cmin。比较不同因素对伏立康唑Cmin的影响及血浆白蛋白(ALB)水平对伏立康唑的临床效果及不良反应发生情况。结果Cmin共测试78次,其中54次(69.2%)Cmin为1.0~5.5 mg/L。ALB及AST是影响伏立康唑Cmin的独立危险因素,ALB与Cmin呈负相关(r=-0.903,P=0.0003);AST与Cmin呈正相关(r=0.872,P=0.0005)。ALB<35 g/L患者有效率低于ALB≥35 g/L,不良反应发生率高于ALB≥35 g/L,差异有统计学意义(P﹤0.05)。结论影响老年重症患者伏立康唑血药谷浓度因素众多,对伏立康唑的血药浓度监测尤为必要。
Objective To explore the importance of monitoring Voriconazole trough serum concentration(Cmin)in severe elderly patients.Methods From January 2014 to December 2018,a retrospective analysis was used to analyze 43 cases who admitted to the Third Affiliated Hospital of Anhui Medical University with severe elderly patients.All patients were treated with Voriconazole,monitored and observed for Cmin.The effects of different factors on the blood drug Cmin of Voriconazole and the clinical effects and adverse reactions of plasma albumin(ALB)on voriconazole were compared.Results The Cmin was tested 78 times and 54 times(69.2%)of Cmin was 1.0~5.5 mg/L.ALB and AST were independent risk factors for Cmin,and ALB was negatively correlated with Cmin(r=-0.903,P=0.0003).AST was positively correlated with serum concentration(r=0.872,P=0.0005).The effective rate of ALB<35 g/L was lower than that of ALB≥35 g/L,and the incidence of adverse reactions was higher than that of ALB≥35 g/L,the differences were statistically significant(P<0.05).Conclusion There are many factors that affect the concentration of voriconazole in the severe elderly patients.It is particularly necessary to monitor the concentration of Voriconazole in the blood.
作者
王佳
徐丙发
秦侃
WANG Jia;XU Bingfa;QIN Kan(Department of pharmacy,the Third Affiliated Hospital of Anhui Medical University,Anhui Province,Hefei230061,China)
出处
《中国医药导报》
CAS
2019年第33期107-110,共4页
China Medical Herald
基金
安徽省“十三五”医疗卫生重点专科建设项目(皖卫教科[2017]30号)
安徽省合肥市卫计委应用医学研究项目(hwk2016yb004)
关键词
重症老年患者
伏立康唑
血药谷浓度
Severe elderly patient
Voriconazole
Trough serum concentration
