摘要
目的探讨胃癌组织中细胞外基质金属蛋白酶诱导因子(CD147)、基质金属蛋白酶9(MMP-9)、人表皮生长因子受体2(HER-2)的表达与患者临床病理特征及预后的相关性.方法收集台州市第一人民医院2016年6月至2018年6月行手术切除的胃癌组织标本80例为观察组;同时选择距癌灶5 cm以上且经病理证实为胃黏膜癌旁正常组织60例为对照组.胃癌组织中CD147、MMP-9及HER-2表达采用免疫组织化学SP法检测.比较两组CD147、MMP-9及HER-2蛋白阳性表达情况,不同病理特征CD147、MMP-9及HER-2蛋白表达阳性率,及不同预后CD147、MMP-9及HER-2蛋白表达阳性率.结果观察组CD147阳性率(73.75%)、MMP-9阳性率(76.25%)及HER-2阳性率(42.50%)均高于对照组(21.67%、25.00%和5.00),差异均有统计学意义(χ^2=37.233、36.288、24.797,均P<0.05).不同性别、不同年龄、不同肿瘤直径和分化程度CD147、MMP-9及HER-2蛋白阳性表达率差异均无统计学意义(均P>0.05);有淋巴结转移CD147阳性率(93.88%)、MMP-9阳性率(95.92%)和HER-2阳性率(61.22%)高于无淋巴结转移(41.94%、45.16%和12.90%),差异均有统计学意义(χ^2=26.462、27.012、18.142,均P<0.05).死亡组CD147阳性率(96.15%)、MMP-9阳性率(92.31%)和HER-2阳性率(69.23%)均高于存活组(62.96%、68.52%和29.63%),差异均有统计学意义(χ^2=9.987、5.484、11.263,均P<0.05).结论胃癌组织中CD147、MMP-9及HER-2蛋白高表达,且与侵袭和转移密切相关,可成为胃癌预后新标志物及治疗新靶点.
Objective To investigate the correlation between the expression of extracellular matrix metalloproteinase-inducible factor(CD147),matrix metalloproteinase-9(MMP-9)and human epidermal growth factor receptor-2(HER-2)in gastric cancer tissues and clinical pathology and prognosis.Methods From June 2016 to June 2018,80 gastric cancer specimens from the First People's Hospital of Taizhou were collected as observation group,and another 60 normal specimens of gastric mucosa adjacent to cancer were selected as control group.The expressions of CD147,MMP-9 and HER-2 were detected by SP immunohistochemical method.The positive rates of CD147,MMP-9 and HER-2 protein expression,the positive rates of CD147,MMP-9 and HER-2 protein expression in different pathological characteristics,and the positive rates of CD147,MMP-9 and HER-2 protein expression in different prognosis were compared between the two groups.Results The positive rates of CD147(73.75%),MMP-9(76.25%)and HER-2(42.50%)in the observation group were higher than those in the control group(21.67%,25.00%,5.00%),the differences were statistically significant(χ^2=37.233,36.288,24.797,all P<0.05).There were no statisticallysignificant differences in the positive expression rates of CD 147,MMP-9 and HER-2 protein among different gender,age,tumor diameter and differentiation(all P>0.05).The positive rates of CD147(93.88%),MMP-9(95.92%)and HER-2(61.22%)with lymph node metastasis were higher than those without lymph node metastasis(41.94%,45.16%,12.90%),the differences were statistically significant(χ^2=26.462,27.012,18.142,all P<0.05).The positive rates of CD147(96.15%),MMP-9(92.31%)and HER-2(69.23%)in the death group were higher than those in the survival group(62.96%,68.52%,29.63%),the differences were statistically significant(χ^2=9.987,5.484,11.263,all P<0.05).Conclusion High expression of CD147,MMP-9 and HER-2 proteins in gastric cancer tissues is closely related to invasion and metastasis,which can become a new prognostic marker and therapeutic target of gastric cancer.
作者
刘炳辉
潘冰
Liu Binghui;Pan Bing(Department of Pathology,the First Peoples Hospital of Taizhou,Taizhou,Zhejiang 318020,China)
出处
《中国基层医药》
CAS
2019年第22期2694-2698,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
胃肿瘤
胃黏膜癌旁组织
细胞外基质金属蛋白酶诱导因子
基质金属蛋白酶9
人表皮生长因子受体2
肿瘤直径
分化程度
淋巴结转移
预后
Gastric cancer
Paracancerous tissue of gastric mucosa
Extracellular matrix metalloproteinase-inducing factor
Matrix metalloproteinase-9
Human epidermal growth factor receptor-2
Tumor diameter
Differentiation degree
Lymph node metastasis
Prognosis
