摘要
目的:探讨Smoothened(SMO)、STAT3和MMP-9蛋白在三阴性乳腺癌组织中的表达及临床意义。方法:应用免疫组织化学SP法检测33例三阴性乳腺癌、30例乳腺增生及18例癌旁正常乳腺组织中SMO、STAT3、MMP-9蛋白的表达情况,并分析它们与三阴性乳腺癌临床病理因素及预后的关系。结果:在三阴性乳腺癌和乳腺增生组织中SMO蛋白的阳性表达率分别为90.9%和60.0%,STAT3蛋白的阳性表达率分别为96.9%和73.3%,MMP-9蛋白的阳性表达率分别为90.9%和36.7%,三者在正常乳腺组织中均无表达;SMO、STAT3和MMP-9蛋白表达在三阴性乳腺癌、乳腺增生及正常乳腺组织中均有显著差异(P<0.05)。SMO和STAT3的表达与乳腺癌组织学分级、pTNM分期有关(P<0.05),其表达均随着组织学分级和临床分期的增高而增高;MMP-9的表达与淋巴结转移有关(P<0.01)。SMO和STAT3(r=0.361,P<0.05)、SMO和MMP-9(r=0.633,P<0.01)、MMP-9和STAT3(r=0.803,P<0.01)在三阴性乳腺癌中的表达均呈正相关。SMO的表达及pTNM分期与三阴性乳腺癌患者的生存时间有关(P<0.05)。结论:SMO、STAT3和MMP-9在三阴性乳腺癌发生发展过程中可能具有重要作用,可作为三阴性乳腺癌患者治疗的重要靶标。
Objective：To investigate the expressions and clinical significances of SMO , STAT3 and MMP-9 in triple negative breast cancer （ TNBC） .Methods：The expressions of SMO , STAT3 and MMP-9 were immunohistochemically detected in 33 cases of TNBC, 30 cases of mammary hyperplasia and 18 cases of normal breast tissue , and the relationships among SMO , STAT3 and MMP-9 and clinicopathological parameters and prognosis of TNBC patients were analyzed .Results：In TNBC and mammary hyperplasia tissue , the positive expression rates of SMO were 90.9%and 60.0%,the positive expression rates of STAT3 were 96.9% and 73.3%, the positive expression rates of MMP-9 were 90.9% and 36.7%, respectively, however, expressions of them were completely absent in normal breast tissue .The significant correlations were observed between expressions of SMO , STAT3 and MMP-9 in TNBC, mammary hyperplasia and normal breast tissue （P〈0.05）.The expression of SMO and STAT3 was correlated with superior histologic grade and tumor stage .The expression of MMP-9 was correlated with metastasis of lymph node .The positive correlation was manifested between SMO and STAT3（r=0.361,P〈0.05）,between SMO and MMP-9 （r=0.633,P〈0.01）,between MMP-9 and STAT3 （r=0.803,P〈0.01） in TNBC.The survival time of TNBC patients was correlated with SMO expression and pTNM （P〈0.05）.Conclusion：SMO, STAT3 and MMP-9 may play important roles in development of TNBC and may be an important therapeutic target in TNBC .
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2014年第6期821-824,830,共5页
Chinese Journal of Immunology
