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GnRH拮抗剂灵活方案与固定方案在卵巢正常反应患者行IVF治疗中的对比研究 被引量:1

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摘要 辅助生殖技术中的促排卵方案,在保证一定数量卵泡同步发育的同时,需抑制体内早发黄体生成素峰(LH峰),GnRH拮抗剂能与垂体的GnRH受体相结合,快速抑制Gn(FSH,LH)的释放,无需垂体降调节,作用时间短,停药后能迅速解除对垂体的抑制,目前已在临床广泛应用。与GnRH激动剂方案相比,GnRH拮抗剂方案能减少Gn的使用时间及用量,且降低OHSS的发生率。但GnRH拮抗剂何时开始使用,无统一标准,目前有固定方案和灵活方案两种:固定方案是在使用Gn第5~6天开始添加GnRH拮抗剂;灵活方案:即在优势卵泡直径≥14mm或优势卵泡直径≥12mm且雌二醇>300pg/ml时添加[1]。本研究对比了120例行GnRH拮抗剂方案的患者,比较固定方案与灵活方案的治疗效果,以期为临床材料方案的选择提供参考。
作者 张帆
出处 《中国现代医药杂志》 2019年第11期42-44,共3页 Modern Medicine Journal of China
基金 广西壮族自治区卫生健康委员会自筹经费科研课题立项项目(编号:Z20190124)
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