摘要
随着经济水平的发展,炎症性肠病(IBD)患者逐渐增多。在研究IBD疾病的发病机制中,鼠类柠檬酸杆菌(C.rodentium)感染是常用的模型之一,可用于观察肠道宿主及环境因素对其易感性的影响。宿主抗C.rodentium感染的能力与肠道菌群、肠道上皮细胞及免疫细胞有关,其中肠道菌群是近期研究热点,可能为临床治疗提供新思路和新方法。乳酸杆菌(Lactobacillus)和分节丝状菌(SFB)可能通过促进细胞因子产生来增强宿主对C.rodentium的抗性;毛螺菌科(Lachnospiraceae)的细菌可能促进短链脂肪酸的产生,从而提高宿主对C.rodentium感染的抗性;嗜粘蛋白-艾克曼菌(Akkermansia muciniphila)则可能通过降解肠道粘液层,破坏肠道上皮屏障而减弱宿主对C.rodentium感染的抗性。本文围绕上述肠道细菌对宿主抗C.rodentium感染的作用和机制进行总结。
With the development of economic level,inflammatory bowel disease(IBD)patients are gradually increasing.Citrobacter rodentium infection is one of the commonly used models to study the pathogenesis of IBD.It can be used to observe the influence of host and environmental factors on host susceptibility.The host's ability to resist C.rodentium infection is associated with gut microbiota,intestinal epithelial cells and immune cells,among which gut microbiota is hot research topic,and can provide new ideas and methods for clinical treatment.Lactobacillus and Segmented filamentous bacterium can enhance cytokine production and increase the host resistance to Citrobacter infection;Lachnospiraceae produces short-chain fatty acids which increase the host resistance to Citrobacter infection;Akkermansia muciniphila can degree the intestinal mucosal layer,disrupt intestinal barrier,and decrease the host resistance to C.rodentium infection.This review will focus on the role of gut bacteria on host resistance to C.rodentium infection.
作者
谢园
陈玲霞
刘雨霞
谢璐
吴雄健
刘志平
XIE Yuan;CHEN Ling-xia;LIU Yu-xia;XIE Lu;WU Xiong-jian;LIU Zhi-ping(Gannan Medical University,Ganzhou,Jiangxi 341000;Gannan Medical University,School of Basic Medicine,Ganzhou,Jiangxi 341000;Gannan Medical University,Center for Immunology,Ganzhou,Jiangxi 341000;Gannan Medical University,Department of Gastroenterology,The First Affiliated Hospital,Ganzhou,Jiangxi 341000)
出处
《赣南医学院学报》
2019年第10期973-978,1013,共7页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
国家自然科学基金项目(31560260,31960163)
江西省自然科学基金项目(20151BAB205061,20171ACB20024,20181BAB205032)
赣南医学院人才启动基金项目(QD201404)
赣南医学院2018年度研究生创新课题(YC2018-X009)
关键词
肠道菌群
鼠类柠檬酸杆菌
肠道炎症
Gut microbiota
Citrobacter rodentium
Intestinal inflammation
